The role of seminal vesicle secretion (SVS) 7 protein in bone homeostasis

William Cundawan

    Research output: ThesisDoctoral Thesis

    371 Downloads (Pure)

    Abstract

    [Truncated abstract] Bone, a living tissue that forms our skeletal frame, is continuously remodelled throughout life by the complementary activities of bone-resorbing osteoclasts and boneforming osteoblasts. The cell-to-cell interaction between osteoclasts and osteoblasts is tightly regulated to achieve bone homeostasis and is governed by the production and exchange of various coupling factors. However, the nature and identity of these factors are still largely obscure. In search for novel osteoclast-derived coupling factors, we have previously employed subtractive hybridization-based differential screening to
    probe for differentially expressed genes between osteoclasts and their mononuclear progenitors. Using this approach, we have successfully identified seminal vesicle secretion (Svs) 7, known as calcium (Ca2+) transport inhibitor (Caltrin), as a candidate gene that was robustly upregulated during receptor activator of NF-κB ligand (RANKL)-induced bone marrow macrophages (BMM) differentiation into mature osteoclasts (Davey 2008; Phan 2004). Svs7 is exclusively expressed by osteoclasts in bone and liberated as a secreted factor.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Publication statusUnpublished - 2013

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