[Truncated abstract] Bone homeostasis is maintained by the bone remodelling process which involves bone resorption by osteoclasts and bone formation by osteoblasts. Disruption of this balanced process towards increased osteoclastic activity is associated with bone diseases such as osteoporosis which has devastating social and psychological consequences. The bone resorbing osteoclasts are large multinucleated cells formed from the fusion of monocyte precursor cells stimulated with the receptor activator of NF-κB ligand (RANKL) and M-CSF. Interestingly, the RANKL associated cell signalling cascades share a common kinase, Protein Kinase C (PKC). PKCs are a family of serine/threonine kinases consisting of at least 10 members classed into three groups: the classical (Phospholipid, DAG and Ca2+ dependent) PKC-α, -βI, -βII and -γ; novel (Phospholipid and DAG dependent) PKC-δ, -ε, -η and -θ; and atypical (Phospholipid dependent) PKC-λ/ι and -ζ. PKCs are involved in numerous signalling pathways including cell proliferation, differentiation and apoptosis.
|Qualification||Doctor of Philosophy|
|Publication status||Unpublished - 2011|