Abstract
Objectives: To determine whether preoperative steroids can improve hearing outcomes in cochlear implantation (CI). Methods: This is a randomized controlled trial involving 30 postlingual deaf CI patients. Subjects had preoperative thresholds of better than or equal to 80 dB at 125 and 250 Hz, and better than or equal to 90 dB at 500 and 1,000 Hz. The subjects were randomized to a control group, an oral steroid group (receiving 1 mg/kg/day of prednisolone for 6 days prior to surgery), or a transtympanic steroid group (receiving a single dose of 0.5 mL of 10 mg/mL dexamethasone at 24 h prior to surgery). Results: The subjects receiving transtympanic steroids had a significant decrease in the pure tone average over 3 months compared to the control and oral steroid group, which persisted over 12 months (p < 0.05). Conclusion: A single dose of preoperative transtympanic steroids prior to CI appears to have a beneficial effect, at least in the short term, with minimal effects seen in the longer term.
| Original language | English |
|---|---|
| Pages (from-to) | 292-302 |
| Number of pages | 11 |
| Journal | Audiology and Neurotology |
| Volume | 22 |
| Issue number | 4-5 |
| DOIs | |
| Publication status | Published - 2018 |
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The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation : Results of a Randomized Controlled Trial. / Kuthubutheen, Jafri; Joglekar, Samidha; Smith, Leah; Friesen, Lendra; Smilsky, Kari; Millman, Tara; Ng, Amy; Shipp, David; Coates, Harvey; Arnoldner, Christoph; Nedzelski, Julian; Chen, Joseph; Lin, Vincent.
In: Audiology and Neurotology, Vol. 22, No. 4-5, 2018, p. 292-302.Research output: Contribution to journal › Article
TY - JOUR
T1 - The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation
T2 - Results of a Randomized Controlled Trial
AU - Kuthubutheen, Jafri
AU - Joglekar, Samidha
AU - Smith, Leah
AU - Friesen, Lendra
AU - Smilsky, Kari
AU - Millman, Tara
AU - Ng, Amy
AU - Shipp, David
AU - Coates, Harvey
AU - Arnoldner, Christoph
AU - Nedzelski, Julian
AU - Chen, Joseph
AU - Lin, Vincent
PY - 2018
Y1 - 2018
N2 - Objectives: To determine whether preoperative steroids can improve hearing outcomes in cochlear implantation (CI). Methods: This is a randomized controlled trial involving 30 postlingual deaf CI patients. Subjects had preoperative thresholds of better than or equal to 80 dB at 125 and 250 Hz, and better than or equal to 90 dB at 500 and 1,000 Hz. The subjects were randomized to a control group, an oral steroid group (receiving 1 mg/kg/day of prednisolone for 6 days prior to surgery), or a transtympanic steroid group (receiving a single dose of 0.5 mL of 10 mg/mL dexamethasone at 24 h prior to surgery). Results: The subjects receiving transtympanic steroids had a significant decrease in the pure tone average over 3 months compared to the control and oral steroid group, which persisted over 12 months (p < 0.05). Conclusion: A single dose of preoperative transtympanic steroids prior to CI appears to have a beneficial effect, at least in the short term, with minimal effects seen in the longer term.
AB - Objectives: To determine whether preoperative steroids can improve hearing outcomes in cochlear implantation (CI). Methods: This is a randomized controlled trial involving 30 postlingual deaf CI patients. Subjects had preoperative thresholds of better than or equal to 80 dB at 125 and 250 Hz, and better than or equal to 90 dB at 500 and 1,000 Hz. The subjects were randomized to a control group, an oral steroid group (receiving 1 mg/kg/day of prednisolone for 6 days prior to surgery), or a transtympanic steroid group (receiving a single dose of 0.5 mL of 10 mg/mL dexamethasone at 24 h prior to surgery). Results: The subjects receiving transtympanic steroids had a significant decrease in the pure tone average over 3 months compared to the control and oral steroid group, which persisted over 12 months (p < 0.05). Conclusion: A single dose of preoperative transtympanic steroids prior to CI appears to have a beneficial effect, at least in the short term, with minimal effects seen in the longer term.
KW - Cochlear implantation
KW - Dexamethasone
KW - Hearing preservation
KW - Steroid
UR - http://www.scopus.com/inward/record.url?scp=85040739522&partnerID=8YFLogxK
U2 - 10.1159/000485310
DO - 10.1159/000485310
M3 - Article
VL - 22
SP - 292
EP - 302
JO - Audiology & Neuro-Otology
JF - Audiology & Neuro-Otology
SN - 1420-3030
IS - 4-5
ER -