The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of a Randomized Controlled Trial

Jafri Kuthubutheen, Samidha Joglekar, Leah Smith, Lendra Friesen, Kari Smilsky, Tara Millman, Amy Ng, David Shipp, Harvey Coates, Christoph Arnoldner, Julian Nedzelski, Joseph Chen, Vincent Lin

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Abstract

Objectives: To determine whether preoperative steroids can improve hearing outcomes in cochlear implantation (CI). Methods: This is a randomized controlled trial involving 30 postlingual deaf CI patients. Subjects had preoperative thresholds of better than or equal to 80 dB at 125 and 250 Hz, and better than or equal to 90 dB at 500 and 1,000 Hz. The subjects were randomized to a control group, an oral steroid group (receiving 1 mg/kg/day of prednisolone for 6 days prior to surgery), or a transtympanic steroid group (receiving a single dose of 0.5 mL of 10 mg/mL dexamethasone at 24 h prior to surgery). Results: The subjects receiving transtympanic steroids had a significant decrease in the pure tone average over 3 months compared to the control and oral steroid group, which persisted over 12 months (p < 0.05). Conclusion: A single dose of preoperative transtympanic steroids prior to CI appears to have a beneficial effect, at least in the short term, with minimal effects seen in the longer term.

Original languageEnglish
Pages (from-to)292-302
Number of pages11
JournalAudiology and Neurotology
Volume22
Issue number4-5
DOIs
Publication statusPublished - 2018

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Cochlear Implantation
Hearing
Randomized Controlled Trials
Steroids
Prednisolone
Dexamethasone
Control Groups

Cite this

Kuthubutheen, J., Joglekar, S., Smith, L., Friesen, L., Smilsky, K., Millman, T., ... Lin, V. (2018). The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of a Randomized Controlled Trial. Audiology and Neurotology, 22(4-5), 292-302. https://doi.org/10.1159/000485310
Kuthubutheen, Jafri ; Joglekar, Samidha ; Smith, Leah ; Friesen, Lendra ; Smilsky, Kari ; Millman, Tara ; Ng, Amy ; Shipp, David ; Coates, Harvey ; Arnoldner, Christoph ; Nedzelski, Julian ; Chen, Joseph ; Lin, Vincent. / The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation : Results of a Randomized Controlled Trial. In: Audiology and Neurotology. 2018 ; Vol. 22, No. 4-5. pp. 292-302.
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Kuthubutheen, J, Joglekar, S, Smith, L, Friesen, L, Smilsky, K, Millman, T, Ng, A, Shipp, D, Coates, H, Arnoldner, C, Nedzelski, J, Chen, J & Lin, V 2018, 'The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of a Randomized Controlled Trial' Audiology and Neurotology, vol. 22, no. 4-5, pp. 292-302. https://doi.org/10.1159/000485310

The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation : Results of a Randomized Controlled Trial. / Kuthubutheen, Jafri; Joglekar, Samidha; Smith, Leah; Friesen, Lendra; Smilsky, Kari; Millman, Tara; Ng, Amy; Shipp, David; Coates, Harvey; Arnoldner, Christoph; Nedzelski, Julian; Chen, Joseph; Lin, Vincent.

In: Audiology and Neurotology, Vol. 22, No. 4-5, 2018, p. 292-302.

Research output: Contribution to journalArticle

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AU - Joglekar, Samidha

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AU - Friesen, Lendra

AU - Smilsky, Kari

AU - Millman, Tara

AU - Ng, Amy

AU - Shipp, David

AU - Coates, Harvey

AU - Arnoldner, Christoph

AU - Nedzelski, Julian

AU - Chen, Joseph

AU - Lin, Vincent

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