The role of oxidative stress and cholesterol in animal models of Alzheimer's disease

Gerald Veurink

    Research output: ThesisDoctoral Thesis

    Abstract

    Alzheimer's disease (AD) is the most commonly diagnosed form of dementia in the aged, and is characterised by a progressive decline in memory, language and other cognitive functions, together with deterioration in behavioural, emotional and social skills. The earliest clinical symptoms include episodic memory loss and dysnomia. This is followed by other signs of cortical impairment including apraxia, agnosia, and visuospatial impairment. In advanced stages, victims become mute, cannot walk and are incontinent; they therefore become totally dependent on carers. AD is the third leading cause of death in the aging population after heart disease and cancer. The incidence of AD doubles every 5 years in subjects between the ages of 65 and 85 years, affecting one in three by the age of 80. AD is characterised by the existence of intracellular and extracellular amyloid deposits in the brain. Extracellular amyloid deposits consist of plaques, whereas the deposits within and around blood vessels are referred to as cerebral amyloid angiopathy (CAA). Neurofibrillary tangles (NFT) are characteristically found in AD; however, they are also found in some other neurodegenerative disorders such as tuberose sclerosis, amyotrophic lateral sclerosis, parkinson-dementia complex and dementia pugilistica.
    LanguageEnglish
    QualificationDoctor of Philosophy
    StateUnpublished - 2008

    Fingerprint

    Alzheimer Disease
    Oxidative Stress
    Animal Models
    Cholesterol
    Dementia
    Amyloid Plaques
    Anomia
    Cerebral Amyloid Angiopathy
    Agnosia
    Apraxias
    Neurofibrillary Tangles
    Heart Neoplasms
    Tuberous Sclerosis
    Episodic Memory
    Memory Disorders
    Amyotrophic Lateral Sclerosis
    Neurodegenerative Diseases
    Cognition
    Caregivers
    Blood Vessels

    Cite this

    @phdthesis{299a8639931d4522b6bb54ec5f7b048c,
    title = "The role of oxidative stress and cholesterol in animal models of Alzheimer's disease",
    abstract = "Alzheimer's disease (AD) is the most commonly diagnosed form of dementia in the aged, and is characterised by a progressive decline in memory, language and other cognitive functions, together with deterioration in behavioural, emotional and social skills. The earliest clinical symptoms include episodic memory loss and dysnomia. This is followed by other signs of cortical impairment including apraxia, agnosia, and visuospatial impairment. In advanced stages, victims become mute, cannot walk and are incontinent; they therefore become totally dependent on carers. AD is the third leading cause of death in the aging population after heart disease and cancer. The incidence of AD doubles every 5 years in subjects between the ages of 65 and 85 years, affecting one in three by the age of 80. AD is characterised by the existence of intracellular and extracellular amyloid deposits in the brain. Extracellular amyloid deposits consist of plaques, whereas the deposits within and around blood vessels are referred to as cerebral amyloid angiopathy (CAA). Neurofibrillary tangles (NFT) are characteristically found in AD; however, they are also found in some other neurodegenerative disorders such as tuberose sclerosis, amyotrophic lateral sclerosis, parkinson-dementia complex and dementia pugilistica.",
    keywords = "Alzheimer's disease, Animal models, Cholesterol, Oxidative stress, Alzheimer's animal models, Role of antioxidants, Role of cholesterol",
    author = "Gerald Veurink",
    year = "2008",
    language = "English",

    }

    The role of oxidative stress and cholesterol in animal models of Alzheimer's disease. / Veurink, Gerald.

    2008.

    Research output: ThesisDoctoral Thesis

    TY - THES

    T1 - The role of oxidative stress and cholesterol in animal models of Alzheimer's disease

    AU - Veurink,Gerald

    PY - 2008

    Y1 - 2008

    N2 - Alzheimer's disease (AD) is the most commonly diagnosed form of dementia in the aged, and is characterised by a progressive decline in memory, language and other cognitive functions, together with deterioration in behavioural, emotional and social skills. The earliest clinical symptoms include episodic memory loss and dysnomia. This is followed by other signs of cortical impairment including apraxia, agnosia, and visuospatial impairment. In advanced stages, victims become mute, cannot walk and are incontinent; they therefore become totally dependent on carers. AD is the third leading cause of death in the aging population after heart disease and cancer. The incidence of AD doubles every 5 years in subjects between the ages of 65 and 85 years, affecting one in three by the age of 80. AD is characterised by the existence of intracellular and extracellular amyloid deposits in the brain. Extracellular amyloid deposits consist of plaques, whereas the deposits within and around blood vessels are referred to as cerebral amyloid angiopathy (CAA). Neurofibrillary tangles (NFT) are characteristically found in AD; however, they are also found in some other neurodegenerative disorders such as tuberose sclerosis, amyotrophic lateral sclerosis, parkinson-dementia complex and dementia pugilistica.

    AB - Alzheimer's disease (AD) is the most commonly diagnosed form of dementia in the aged, and is characterised by a progressive decline in memory, language and other cognitive functions, together with deterioration in behavioural, emotional and social skills. The earliest clinical symptoms include episodic memory loss and dysnomia. This is followed by other signs of cortical impairment including apraxia, agnosia, and visuospatial impairment. In advanced stages, victims become mute, cannot walk and are incontinent; they therefore become totally dependent on carers. AD is the third leading cause of death in the aging population after heart disease and cancer. The incidence of AD doubles every 5 years in subjects between the ages of 65 and 85 years, affecting one in three by the age of 80. AD is characterised by the existence of intracellular and extracellular amyloid deposits in the brain. Extracellular amyloid deposits consist of plaques, whereas the deposits within and around blood vessels are referred to as cerebral amyloid angiopathy (CAA). Neurofibrillary tangles (NFT) are characteristically found in AD; however, they are also found in some other neurodegenerative disorders such as tuberose sclerosis, amyotrophic lateral sclerosis, parkinson-dementia complex and dementia pugilistica.

    KW - Alzheimer's disease

    KW - Animal models

    KW - Cholesterol

    KW - Oxidative stress

    KW - Alzheimer's animal models

    KW - Role of antioxidants

    KW - Role of cholesterol

    M3 - Doctoral Thesis

    ER -