The role of NEAT1 and MSLN in bone remodelling

Ziyi Wang

Research output: ThesisDoctoral Thesis

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Abstract

Uncovering new mechanisms that regulate bone remodelling process is important for the treatment of osteoporosis. In this study, we identified Nuclear Enriched Abundant Transcript 1 (NEAT1) as a new long non-coding RNA that regulates the formation of osteoclast and paraspeckles. Additionally, we found that mesothelin (MSLN) acts a potential coupling factor that mediates bone remodelling. Osteoclast derived MSLN promoted migration of osteoblasts, and osteoclast-specific knockout of MSLN in mice resulted in decreased bone volume. Overall, this study provides new insights into the roles of NEAT1 and MSLN in bone biology and their potential as therapeutic targets for osteoporosis treatment.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Xu, Jiake, Supervisor
  • Tickner, Jennifer, Supervisor
Thesis sponsors
Award date8 Jun 2021
DOIs
Publication statusUnpublished - 2021

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