The role of NEAT1 and MSLN in bone remodelling

Ziyi Wang

doi:10.26182/vwfp-zz44

The role of NEAT1 and MSLN in bone remodelling

Ziyi Wang

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

Uncovering new mechanisms that regulate bone remodelling process is important for the treatment of osteoporosis. In this study, we identified Nuclear Enriched Abundant Transcript 1 (NEAT1) as a new long non-coding RNA that regulates the formation of osteoclast and paraspeckles. Additionally, we found that mesothelin (MSLN) acts a potential coupling factor that mediates bone remodelling. Osteoclast derived MSLN promoted migration of osteoblasts, and osteoclast-specific knockout of MSLN in mice resulted in decreased bone volume. Overall, this study provides new insights into the roles of NEAT1 and MSLN in bone biology and their potential as therapeutic targets for osteoporosis treatment.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Xu, Jiake, Supervisor Tickner, Jennifer, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	8 Jun 2021
DOIs	https://doi.org/10.26182/vwfp-zz44
Publication status	Unpublished - 2021

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THESIS - DOCTOR OF PHILOSOPHY - WANG, Ziyi - 2021
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Cite this

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abstract = "Uncovering new mechanisms that regulate bone remodelling process is important for the treatment of osteoporosis. In this study, we identified Nuclear Enriched Abundant Transcript 1 (NEAT1) as a new long non-coding RNA that regulates the formation of osteoclast and paraspeckles. Additionally, we found that mesothelin (MSLN) acts a potential coupling factor that mediates bone remodelling. Osteoclast derived MSLN promoted migration of osteoblasts, and osteoclast-specific knockout of MSLN in mice resulted in decreased bone volume. Overall, this study provides new insights into the roles of NEAT1 and MSLN in bone biology and their potential as therapeutic targets for osteoporosis treatment.",

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AB - Uncovering new mechanisms that regulate bone remodelling process is important for the treatment of osteoporosis. In this study, we identified Nuclear Enriched Abundant Transcript 1 (NEAT1) as a new long non-coding RNA that regulates the formation of osteoclast and paraspeckles. Additionally, we found that mesothelin (MSLN) acts a potential coupling factor that mediates bone remodelling. Osteoclast derived MSLN promoted migration of osteoblasts, and osteoclast-specific knockout of MSLN in mice resulted in decreased bone volume. Overall, this study provides new insights into the roles of NEAT1 and MSLN in bone biology and their potential as therapeutic targets for osteoporosis treatment.

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KW - Osteoblast

KW - Bone remodelling

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M3 - Doctoral Thesis

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The role of NEAT1 and MSLN in bone remodelling

Abstract

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