The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy

Xiaofeng Liu; Yongqiang Zheng; Hao Li; Yiyang Ma; Ruomu Cao; Zhikai Zheng; Yuchen Tian; Lin Du; Jinshan Zhang; Changqing Zhang; Junjie Gao

doi:10.1016/j.jot.2024.10.003

The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy

Xiaofeng Liu
, Yongqiang Zheng
, Hao Li
, Yiyang Ma
, Ruomu Cao
, Zhikai Zheng
, Yuchen Tian
, Lin Du
, Jinshan Zhang
, Changqing Zhang
, Junjie Gao

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Osteoarthritis (OA) is a progressive degenerative disease affected by many factors, and there is currently no effective treatment. In recent years, the latest progress in metabolomics in OA research has revealed several metabolic pathways and new specific metabolites involved in OA. Metabolites play significant roles in the identification and management of OA. This review looks back on the development history of metabolomics and the progress of this technology in OA as well as its potential clinical applications. It summarizes the applications of metabolites in the field of OA and future research directions. This understanding will advance the identification of metabolic treatment goals for OA.

Original language	English
Pages (from-to)	56-70
Number of pages	15
Journal	Journal of Orthopaedic Translation
Volume	50
DOIs	https://doi.org/10.1016/j.jot.2024.10.003
Publication status	Published - Jan 2025
Externally published	Yes

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title = "The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy",

abstract = "Osteoarthritis (OA) is a progressive degenerative disease affected by many factors, and there is currently no effective treatment. In recent years, the latest progress in metabolomics in OA research has revealed several metabolic pathways and new specific metabolites involved in OA. Metabolites play significant roles in the identification and management of OA. This review looks back on the development history of metabolomics and the progress of this technology in OA as well as its potential clinical applications. It summarizes the applications of metabolites in the field of OA and future research directions. This understanding will advance the identification of metabolic treatment goals for OA.",

author = "Xiaofeng Liu and Yongqiang Zheng and Hao Li and Yiyang Ma and Ruomu Cao and Zhikai Zheng and Yuchen Tian and Lin Du and Jinshan Zhang and Changqing Zhang and Junjie Gao",

year = "2025",

month = jan,

doi = "10.1016/j.jot.2024.10.003",

language = "English",

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journal = "Journal of Orthopaedic Translation",

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TY - JOUR

T1 - The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy

AU - Liu, Xiaofeng

AU - Zheng, Yongqiang

AU - Li, Hao

AU - Ma, Yiyang

AU - Cao, Ruomu

AU - Zheng, Zhikai

AU - Tian, Yuchen

AU - Du, Lin

AU - Zhang, Jinshan

AU - Zhang, Changqing

AU - Gao, Junjie

PY - 2025/1

Y1 - 2025/1

N2 - Osteoarthritis (OA) is a progressive degenerative disease affected by many factors, and there is currently no effective treatment. In recent years, the latest progress in metabolomics in OA research has revealed several metabolic pathways and new specific metabolites involved in OA. Metabolites play significant roles in the identification and management of OA. This review looks back on the development history of metabolomics and the progress of this technology in OA as well as its potential clinical applications. It summarizes the applications of metabolites in the field of OA and future research directions. This understanding will advance the identification of metabolic treatment goals for OA.

AB - Osteoarthritis (OA) is a progressive degenerative disease affected by many factors, and there is currently no effective treatment. In recent years, the latest progress in metabolomics in OA research has revealed several metabolic pathways and new specific metabolites involved in OA. Metabolites play significant roles in the identification and management of OA. This review looks back on the development history of metabolomics and the progress of this technology in OA as well as its potential clinical applications. It summarizes the applications of metabolites in the field of OA and future research directions. This understanding will advance the identification of metabolic treatment goals for OA.

U2 - 10.1016/j.jot.2024.10.003

DO - 10.1016/j.jot.2024.10.003

M3 - Review article

C2 - 39868350

SN - 2214-031X

VL - 50

SP - 56

EP - 70

JO - Journal of Orthopaedic Translation

JF - Journal of Orthopaedic Translation

ER -

The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy

Abstract

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