The role of mesothelin (MSLN) in bone homeostasis

Mingli Yang

The role of mesothelin (MSLN) in bone homeostasis

Mingli Yang

Research output: Thesis › Doctoral Thesis

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Abstract

The role or Mesothelin (MSLN) in bone homeostasis is not known. Here, we showed that MSLN KO mice display an osteoporotic phenotype, accompanied with an increased osteoclast number. Full-length MSLN suppresses osteoclast differentiation and bone resorption. Additionally, MSLN deficiency leads to attenuated osteoblast differentiation and function. Treatment with full-length MSLN in vivo protects against osteolysis induced by calvarial lipopolysaccharide (LPS) injection. The exact molecular mechanisms by which MSLN regulates bone cells remains to be fully elucidated. Nevertheless, MSLN is a novel regulator in bone remodelling and may represent a potential therapeutic target for the treatment of bone disorders.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Xu, Jiake, Supervisor Tickner, Jennifer, Supervisor
Award date	8 Nov 2016
Publication status	Unpublished - 2016

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THESIS - DOCTOR OF PHILOSOPHY - YANG Mingli - 2016
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title = "The role of mesothelin (MSLN) in bone homeostasis",

abstract = "The role or Mesothelin (MSLN) in bone homeostasis is not known. Here, we showed that MSLN KO mice display an osteoporotic phenotype, accompanied with an increased osteoclast number. Full-length MSLN suppresses osteoclast differentiation and bone resorption. Additionally, MSLN deficiency leads to attenuated osteoblast differentiation and function. Treatment with full-length MSLN in vivo protects against osteolysis induced by calvarial lipopolysaccharide (LPS) injection. The exact molecular mechanisms by which MSLN regulates bone cells remains to be fully elucidated. Nevertheless, MSLN is a novel regulator in bone remodelling and may represent a potential therapeutic target for the treatment of bone disorders.",

keywords = "Mesothelin, Bone Homeostasis, Osteoclast, Osteoblast, Bone remodelling, Osteoporosis",

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AU - Yang, Mingli

PY - 2016

Y1 - 2016

N2 - The role or Mesothelin (MSLN) in bone homeostasis is not known. Here, we showed that MSLN KO mice display an osteoporotic phenotype, accompanied with an increased osteoclast number. Full-length MSLN suppresses osteoclast differentiation and bone resorption. Additionally, MSLN deficiency leads to attenuated osteoblast differentiation and function. Treatment with full-length MSLN in vivo protects against osteolysis induced by calvarial lipopolysaccharide (LPS) injection. The exact molecular mechanisms by which MSLN regulates bone cells remains to be fully elucidated. Nevertheless, MSLN is a novel regulator in bone remodelling and may represent a potential therapeutic target for the treatment of bone disorders.

AB - The role or Mesothelin (MSLN) in bone homeostasis is not known. Here, we showed that MSLN KO mice display an osteoporotic phenotype, accompanied with an increased osteoclast number. Full-length MSLN suppresses osteoclast differentiation and bone resorption. Additionally, MSLN deficiency leads to attenuated osteoblast differentiation and function. Treatment with full-length MSLN in vivo protects against osteolysis induced by calvarial lipopolysaccharide (LPS) injection. The exact molecular mechanisms by which MSLN regulates bone cells remains to be fully elucidated. Nevertheless, MSLN is a novel regulator in bone remodelling and may represent a potential therapeutic target for the treatment of bone disorders.

KW - Mesothelin

KW - Bone Homeostasis

KW - Osteoclast

KW - Osteoblast

KW - Bone remodelling

KW - Osteoporosis

M3 - Doctoral Thesis

ER -

The role of mesothelin (MSLN) in bone homeostasis

Abstract

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