TY - JOUR
T1 - The Role of Long Non-coding RNA, Nuclear Enriched Abundant Transcript 1 (NEAT1) in Cancer and Other Pathologies
AU - Zhang, Miao
AU - Guo, Jianmin
AU - Liu, Lifei
AU - Huang, Mei
AU - Li, Yuexuan
AU - Bennett, Samuel
AU - Xu, Jia Ke
AU - Zou, Jun
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China (No. 81871835), Shanghai Frontiers Science Research Base of Exercise and Metabolic Health and Shanghai Key Laboratory for Human Athletic Ability Development and Support (Shanghai University of Sport) (No. 11DZ2261100). We would like to thank all authors for contributing to this study.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/6
Y1 - 2022/6
N2 - Nuclear enriched abundant transcript 1 (NEAT1), consisting of two kinds of lncRNAs of 3.7 kB NEAT1-1 and 23 kB NEAT1-2, can be highly expressed in organs and tissues such as the ovary, prostate, colon, and pancreas, and is involved in paraspeckle formation and mRNA editing and gene expression. Therefore, NEAT1 is a potential biomarker for the treatment of a variety of diseases, which may be caused by two factors (isoforms of NEAT1 and NEAT1 sponging miRNA as ceRNA). However, there is still much confusion about the mechanism and downstream effector between the abnormal expression of NEAT1 and various diseases. This review summarizes recent research progress on NEAT1 in cancer and other pathologies and provides a more reliable theoretical basis for the treatment of related diseases.
AB - Nuclear enriched abundant transcript 1 (NEAT1), consisting of two kinds of lncRNAs of 3.7 kB NEAT1-1 and 23 kB NEAT1-2, can be highly expressed in organs and tissues such as the ovary, prostate, colon, and pancreas, and is involved in paraspeckle formation and mRNA editing and gene expression. Therefore, NEAT1 is a potential biomarker for the treatment of a variety of diseases, which may be caused by two factors (isoforms of NEAT1 and NEAT1 sponging miRNA as ceRNA). However, there is still much confusion about the mechanism and downstream effector between the abnormal expression of NEAT1 and various diseases. This review summarizes recent research progress on NEAT1 in cancer and other pathologies and provides a more reliable theoretical basis for the treatment of related diseases.
KW - Cancer
KW - lncRNAs
KW - NEAT1
KW - Noncancerous
UR - http://www.scopus.com/inward/record.url?scp=85117853943&partnerID=8YFLogxK
U2 - 10.1007/s10528-021-10138-8
DO - 10.1007/s10528-021-10138-8
M3 - Review article
C2 - 34689290
AN - SCOPUS:85117853943
SN - 0006-2928
VL - 60
SP - 843
EP - 867
JO - Biochemical Genetics
JF - Biochemical Genetics
IS - 3
ER -
