The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis

J. Köhn-Gaone, J. Gogoi-Tiwari, G.A. Ramm, J.K. Olynyk, Nina Tirnitz-Parker

    Research output: Contribution to journalLiterature reviewpeer-review

    34 Citations (Scopus)

    Abstract

    © 2016 the American Physiological Society. The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, and the metabolic syndrome has sparked interest in stem cell-like liver progenitor cells (LPCs) as potential candidates for cell therapy and tissue engineering, as an alternative approach to whole organ transplantation. However, LPCs always proliferate in chronic liver diseases with a predisposition to cancer; they have been suggested to play major roles in driving fibrosis, disease progression, and may even represent tumor-initiating cells. Hence, a greater understanding of the factors that govern their activation, communication with other hepatic cell types, and bipotential differentiation as opposed to their potential transformation is needed before their therapeutic potential can be harnessed.
    Original languageEnglish
    Pages (from-to)G143-G154
    Number of pages11
    JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
    Volume310
    Issue number3
    Early online date2 Feb 2016
    DOIs
    Publication statusPublished - 2016

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