The role of kisspeptin in energy balance

Julie-Ann Patricia De Bond

Research output: ThesisDoctoral Thesis

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Abstract

This thesis determined the role of kisspeptin signalling in the brain on the development of obesity. Specifically, alterations in hypothalamic feeding circuits and peripheral metabolic genes were examined in kisspeptin receptor knock out (Kiss1rKO) mice. The results show that a peripheral mechanism altering energy expenditure -operating through uncoupling protein 1 gene expression in brown adipose tissue - is the likely cause. These studies also provide further understanding of the reciprocal relationship between reproduction and metabolism and proposes kisspeptin signalling to be vital for this, providing some therapeutical potential for kisspeptin treatment as a tool for treating obesity.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Smith, Jeremy, Supervisor
  • Waddell, Brendan, Supervisor
Thesis sponsors
Award date22 Mar 2018
DOIs
Publication statusUnpublished - 2018

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