This thesis determined the role of kisspeptin signalling in the brain on the development of obesity. Specifically, alterations in hypothalamic feeding circuits and peripheral metabolic genes were examined in kisspeptin receptor knock out (Kiss1rKO) mice. The results show that a peripheral mechanism altering energy expenditure -operating through uncoupling protein 1 gene expression in brown adipose tissue - is the likely cause. These studies also provide further understanding of the reciprocal relationship between reproduction and metabolism and proposes kisspeptin signalling to be vital for this, providing some therapeutical potential for kisspeptin treatment as a tool for treating obesity.
|Qualification||Doctor of Philosophy|
|Award date||22 Mar 2018|
|Publication status||Unpublished - 2018|