The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

Blair Z Johnson; Andrew W Stevenson; Cecilia M Prêle; Mark W Fear; Fiona M Wood

doi:10.3390/biomedicines8050101

The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

Blair Z Johnson, Andrew W Stevenson, Cecilia M Prêle, Mark W Fear, Fiona M Wood

Research output: Contribution to journal › Article › peer-review

296 Citations (Scopus)

Abstract

The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6's diverse impact on cutaneous wound healing.

Original language	English
Article number	101
Journal	Biomedicines
Volume	8
Issue number	5
DOIs	https://doi.org/10.3390/biomedicines8050101
Publication status	Published - 1 May 2020

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abstract = "The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6's diverse impact on cutaneous wound healing.",

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AU - Fear, Mark W

AU - Wood, Fiona M

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The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

Abstract

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