The role of IL-22 in viral infections: Paradigms and paradoxes

Silvia Gimeno Brias, Gabrielle Stack, Maria A. Stacey, Alec J. Redwood, Ian R. Humphreys

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.
Original languageEnglish
Article number211
JournalFrontiers in Immunology
Issue numberMAY
Publication statusPublished - 30 May 2016
Externally publishedYes


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