The role of gene-environment interactions in the development of food allergy

Melanie R. Neeland, David J. Martino, Katrina J. Allen

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


The rates of IgE-mediated food allergy have increased globally, particularly in developed countries. The rising incidence is occurring more rapidly than changes to the genome sequence would allow, suggesting that environmental exposures that alter the immune response play an important role. Genetic factors may also be used to predict an increased predisposition to these environmental risk factors, giving rise to the concept of gene-environment interactions, whereby differential risk of environmental exposures is mediated through the genome. Increasing evidence also suggests a role for epigenetic mechanisms, which are sensitive to environmental exposures, in the development of food allergy. This paper discusses the current state of knowledge regarding the environmental and genetic risk factors for food allergy and how environmental exposures may interact with immune genes to modify disease risk or outcome.

Original languageEnglish
Pages (from-to)1371-1378
Number of pages8
JournalExpert Review of Gastroenterology and Hepatology
Issue number11
Publication statusPublished - 2 Nov 2015


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