Abstract
Aims
To study the role of preoperative steroids in animal and humans receiving a cochlear implant (Cl)
Methods
24 guinea
pigs were randomised into a control group, and groups receiving 1 or 5 days of preoperative steroids. 30 adult Cl candidates
were randomised to a control group, a 6 day oral steroid group or a day prior transtympanic steroid group.Hearing and speech
outcomes were assessed for 12 months.
Results
In the animal study, groups receiving dexamethasone had less hearing loss
and greater neuronal densities. In the human study, subjects receiving transtympanic steroids experienced less hearing loss
over 12 months
Conclusion
Extended preoperative steroids are beneficial in Cl surgery.
To study the role of preoperative steroids in animal and humans receiving a cochlear implant (Cl)
Methods
24 guinea
pigs were randomised into a control group, and groups receiving 1 or 5 days of preoperative steroids. 30 adult Cl candidates
were randomised to a control group, a 6 day oral steroid group or a day prior transtympanic steroid group.Hearing and speech
outcomes were assessed for 12 months.
Results
In the animal study, groups receiving dexamethasone had less hearing loss
and greater neuronal densities. In the human study, subjects receiving transtympanic steroids experienced less hearing loss
over 12 months
Conclusion
Extended preoperative steroids are beneficial in Cl surgery.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Supervisors/Advisors |
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| Award date | 15 Nov 2017 |
| DOIs | |
| Publication status | Unpublished - 2017 |