[Truncated abstract] Bone is a metabolically active tissue that is continuously remoulded, shaped and repaired in a process termed bone remodelling. The remodelling process is primarily involved in the maintenance of bone structure and function during adult life. It is a complex, tightly regulated process that is carried out by two keys cell types: osteoclasts and osteoblasts. Osteoclasts originate for haematopoietic progenitor cells in the bone marrow. They are multinucleated giant cells formed by the fusion of mononuclear precursor cells in a process termed osteoclastogenesis. Two key factors regulating this process are RANKL and M-CSF. Osteoclasts are the principal resorptive cell of bone, playing an important role in the formation of the skeleton and regulation of bone mass. Osteoblasts are derived from mesenchymal stem cells present in the bone marrow. The primary function of the osteoblast is bone formation. Therefore, osteoblasts have a role in the formation of the skeleton as well as continued bone growth and remodelling. Osteoblasts also play a role in osteoclast formation as they secrete RANKL and OPG. Mature osteoblasts have the potential to either incorporate into the newly formed matrix and become terminally differentiated cells termed osteocytes or become cells that line the bone surface.
|Qualification||Doctor of Philosophy|
|Publication status||Unpublished - 2011|