The role of CD44 in epithelial–mesenchymal transition and cancer development

Hanxiao Xu; Yijun Tian; Xun Yuan; Hua Wu; Qian Liu; Richard G. Pestell; Kongming Wu

doi:10.2147/OTT.S95470

The role of CD44 in epithelial–mesenchymal transition and cancer development

Hanxiao Xu, Yijun Tian, Xun Yuan, Hua Wu, Qian Liu, Richard G. Pestell, Kongming Wu

Research output: Contribution to journal › Review article › peer-review

201 Citations (Scopus)

Abstract

CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially identified as a receptor for hyaluronan that participates in both physiological and pathological processes. CD44 is found to be closely linked to the development of various solid tumors. Molecular studies have revealed that high CD44 expression was correlated with the phenotypes of cancer stem cells and epithelial–mesenchymal transition, thereby contributing to tumor invasion, metastasis, recurrence, and chemoresistance. Correspondingly, blockade of CD44 has been demonstrated to be capable of attenuating the malignant phenotype, slowing cancer progression, and reversing therapy resistance. Clinical analyses showed that high CD44 expression is associated with poor survival of various cancer patients, indicating that CD44 can be a potential prognostic marker. In this review, we summarize recent research progress of CD44 on tumor biology and the clinical significance of CD44.

Original language	English
Pages (from-to)	3783-3792
Number of pages	10
Journal	OncoTargets and Therapy
Volume	8
DOIs	https://doi.org/10.2147/OTT.S95470
Publication status	Published - 16 Dec 2015
Externally published	Yes

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title = "The role of CD44 in epithelial–mesenchymal transition and cancer development",

abstract = "CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially identified as a receptor for hyaluronan that participates in both physiological and pathological processes. CD44 is found to be closely linked to the development of various solid tumors. Molecular studies have revealed that high CD44 expression was correlated with the phenotypes of cancer stem cells and epithelial–mesenchymal transition, thereby contributing to tumor invasion, metastasis, recurrence, and chemoresistance. Correspondingly, blockade of CD44 has been demonstrated to be capable of attenuating the malignant phenotype, slowing cancer progression, and reversing therapy resistance. Clinical analyses showed that high CD44 expression is associated with poor survival of various cancer patients, indicating that CD44 can be a potential prognostic marker. In this review, we summarize recent research progress of CD44 on tumor biology and the clinical significance of CD44.",

keywords = "CD44, Epithelial–mesenchymal transition, Prognosis, Tumor progression",

author = "Hanxiao Xu and Yijun Tian and Xun Yuan and Hua Wu and Qian Liu and Pestell, {Richard G.} and Kongming Wu",

note = "Publisher Copyright: {\textcopyright} 2015 Xu et al.",

year = "2015",

month = dec,

day = "16",

doi = "10.2147/OTT.S95470",

language = "English",

volume = "8",

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journal = "OncoTargets and Therapy",

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TY - JOUR

T1 - The role of CD44 in epithelial–mesenchymal transition and cancer development

AU - Xu, Hanxiao

AU - Tian, Yijun

AU - Yuan, Xun

AU - Wu, Hua

AU - Liu, Qian

AU - Pestell, Richard G.

AU - Wu, Kongming

PY - 2015/12/16

Y1 - 2015/12/16

N2 - CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially identified as a receptor for hyaluronan that participates in both physiological and pathological processes. CD44 is found to be closely linked to the development of various solid tumors. Molecular studies have revealed that high CD44 expression was correlated with the phenotypes of cancer stem cells and epithelial–mesenchymal transition, thereby contributing to tumor invasion, metastasis, recurrence, and chemoresistance. Correspondingly, blockade of CD44 has been demonstrated to be capable of attenuating the malignant phenotype, slowing cancer progression, and reversing therapy resistance. Clinical analyses showed that high CD44 expression is associated with poor survival of various cancer patients, indicating that CD44 can be a potential prognostic marker. In this review, we summarize recent research progress of CD44 on tumor biology and the clinical significance of CD44.

AB - CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially identified as a receptor for hyaluronan that participates in both physiological and pathological processes. CD44 is found to be closely linked to the development of various solid tumors. Molecular studies have revealed that high CD44 expression was correlated with the phenotypes of cancer stem cells and epithelial–mesenchymal transition, thereby contributing to tumor invasion, metastasis, recurrence, and chemoresistance. Correspondingly, blockade of CD44 has been demonstrated to be capable of attenuating the malignant phenotype, slowing cancer progression, and reversing therapy resistance. Clinical analyses showed that high CD44 expression is associated with poor survival of various cancer patients, indicating that CD44 can be a potential prognostic marker. In this review, we summarize recent research progress of CD44 on tumor biology and the clinical significance of CD44.

KW - CD44

KW - Epithelial–mesenchymal transition

KW - Prognosis

KW - Tumor progression

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U2 - 10.2147/OTT.S95470

DO - 10.2147/OTT.S95470

M3 - Review article

AN - SCOPUS:84949982731

SN - 1178-6930

VL - 8

SP - 3783

EP - 3792

JO - OncoTargets and Therapy

JF - OncoTargets and Therapy

ER -

The role of CD44 in epithelial–mesenchymal transition and cancer development

Abstract

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