TY - JOUR
T1 - The role of breast cancer stem cells in metastasis and therapeutic implications
AU - Velasco-Velázquez, Marco A.
AU - Popov, Vladimir M.
AU - Lisanti, Michael P.
AU - Pestell, Richard G.
N1 - Funding Information:
Supported in part by PASPA-UNAM (Programa de Apoyos para la Superación del Personal Académico-Universidad Nacional Autónoma de México) (M.A.V.-V.) and the NIH (grants R01CA070896 , R01CA075503 , R01CA107382 , R01CA132115 , and R01CA086072 to R.G.P. and R01CA120876 to M.P.L.). The Kimmel Cancer Center was supported by an NIH cancer center core grant ( P30CA56036 to R.G.P.). This project is funded in part from the Marian C. Falk Medical Research Trust and a grant from the Pennsylvania Department of Health (R.G.P.).
PY - 2011/7
Y1 - 2011/7
N2 - Cancer stem cells (CSCs) possess the capacity to self-renew and to generate heterogeneous lineages of cancer cells that comprise tumors. A substantial body of evidence supports a model in which CSCs play a major role in the initiation, maintenance, and clinical outcome of cancers. In contrast, analysis of the role of CSCs in metastasis has been mainly conceptual and speculative. This review summarizes recent data that support the theory of CSCs as the source of metastatic lesions in breast cancer, with a focus on the key role of the microenvironment in the stemness-metastasis link.
AB - Cancer stem cells (CSCs) possess the capacity to self-renew and to generate heterogeneous lineages of cancer cells that comprise tumors. A substantial body of evidence supports a model in which CSCs play a major role in the initiation, maintenance, and clinical outcome of cancers. In contrast, analysis of the role of CSCs in metastasis has been mainly conceptual and speculative. This review summarizes recent data that support the theory of CSCs as the source of metastatic lesions in breast cancer, with a focus on the key role of the microenvironment in the stemness-metastasis link.
UR - http://www.scopus.com/inward/record.url?scp=80052479916&partnerID=8YFLogxK
U2 - 10.1016/j.ajpath.2011.03.005
DO - 10.1016/j.ajpath.2011.03.005
M3 - Review article
C2 - 21640330
AN - SCOPUS:80052479916
SN - 0002-9440
VL - 179
SP - 2
EP - 11
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 1
ER -
