The role of bone marrow derived cells (BMDCs) in burn wound healing

Suzanne Rea

    Research output: ThesisDoctoral Thesis

    278 Downloads (Pure)


    [Truncated abstract] The reparative process that results in scar formation after tissue injury results in permanent functional and aesthetic deficits. Re-epithelialisation of wounds and dermal cell re-population has been thought to be driven by cells peripheral to the wound site. However, recent research has demonstrated that cells originating from the bone marrow can contribute to healing wounds in other tissues and also after incisional injury. The transition from embryonic complete tissue regeneration to adult scar formation and repair after injury may in part be due to these cells originating in the bone marrow, either hematopoietic stem cell derived (HSC), or mesenchymal stem cell derived (MSC), or potentially both. Currently, many studies are focused on the clinical potential of bone marrow stem cells, in particular MSCs.
    However, our current understanding of their role in repair and clinical potential remains limited, particularly with respect to burn injury. This project aims to clarify the role of bone marrow derived cells in burn injury repair, and further explore both HSC and MSC populations in wound repair and scar formation.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Publication statusUnpublished - 2013


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