The role of biomechanics in tendon homeostasis and its impact on tendon scaffold development

Peilin Chen

doi:10.26182/ztxg-6r82

The role of biomechanics in tendon homeostasis and its impact on tendon scaffold development

Peilin Chen

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

Tendon injuries and tendinopathy are one of the most common orthopaedic condition in our community. Inappropriate mechanical loading exerted on tendon in our daily life is a potential culprit. Using advanced bioengineering methods, this thesis addressed how mechanical loading regulate tendon homeostasis and attempt to develop a principle of mechanobiology of tendon to guild clinical rehabilitation of tendon. A naturally derived collagen rope that can provide mechanical support for tendon and ligament regeneration was also developed. Both preclinical and clinical outcomes of this collage scaffold demonstrated the excellent biomechanical and biological performance for tendon and ligament regeneration.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Zheng, Minghao, Supervisor Wang, Tao, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	1 Dec 2021
DOIs	https://doi.org/10.26182/ztxg-6r82
Publication status	Unpublished - 2021

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10.26182/ztxg-6r82

THESIS - DOCTOR OF PHILOSOPHY - CHEN Peilin - 2021 - Part 1
THESIS - DOCTOR OF PHILOSOPHY - CHEN Peilin - 2021 - Part 2
THESIS - DOCTOR OF PHILOSOPHY - CHEN Peilin - 2021 - Part 3
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Cite this

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title = "The role of biomechanics in tendon homeostasis and its impact on tendon scaffold development",

abstract = "Tendon injuries and tendinopathy are one of the most common orthopaedic condition in our community. Inappropriate mechanical loading exerted on tendon in our daily life is a potential culprit. Using advanced bioengineering methods, this thesis addressed how mechanical loading regulate tendon homeostasis and attempt to develop a principle of mechanobiology of tendon to guild clinical rehabilitation of tendon. A naturally derived collagen rope that can provide mechanical support for tendon and ligament regeneration was also developed. Both preclinical and clinical outcomes of this collage scaffold demonstrated the excellent biomechanical and biological performance for tendon and ligament regeneration.",

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school = "The University of Western Australia",

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AB - Tendon injuries and tendinopathy are one of the most common orthopaedic condition in our community. Inappropriate mechanical loading exerted on tendon in our daily life is a potential culprit. Using advanced bioengineering methods, this thesis addressed how mechanical loading regulate tendon homeostasis and attempt to develop a principle of mechanobiology of tendon to guild clinical rehabilitation of tendon. A naturally derived collagen rope that can provide mechanical support for tendon and ligament regeneration was also developed. Both preclinical and clinical outcomes of this collage scaffold demonstrated the excellent biomechanical and biological performance for tendon and ligament regeneration.

KW - Tendon

KW - Ligament

KW - Biomechanics

KW - Biomaterial

KW - Stem cell

KW - Mechanical loading

KW - Orthopaedics

KW - Surgery, Computer-Assisted/methods

U2 - 10.26182/ztxg-6r82

DO - 10.26182/ztxg-6r82

M3 - Doctoral Thesis

ER -

The role of biomechanics in tendon homeostasis and its impact on tendon scaffold development

Abstract

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