The role of autophagy in plant mitochondrial retrograde signalling

Martyna Broda

Research output: ThesisDoctoral Thesis

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In this thesis, the role of senescence and autophagy in mitochondria-to-nuclear retrograde signalling by the ER-bound transcription factor ANAC017 was examined in Arabidopsis. ANAC017 overexpression led to senescing phenotypes similar to autophagy-deficient mutants. Inhibition of autophagy resulted in suppression of antimcin A (AA) stimulated retrograde signalling, whereas autophagy induction primed them for elevated responses to AA. Also, both N- and C-termini of ANAC017 were found to be located in the ER lumen, indicating a complex process is required to release it to the nucleus. Together, these results suggest a novel model for ANAC017 activation of retrograde signalling that involves autophagy.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
  • Millar, Harvey, Supervisor
  • Lee, Alex, Supervisor
  • Van Aken, Olivier, Supervisor
Thesis sponsors
Award date11 Jun 2020
Publication statusUnpublished - 2020


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