The RNA Coregulator SRA, its Binding Proteins and Nuclear Receptor Signaling Activity

S.M. Colley, K.R. Iyer, Peter Leedman

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Nuclear receptor (NR) coregulators are key modulators of hormone signaling. Discovery of steroid receptor RNA activator (SRA), a coregulator that is active as a RNA, transformed thinking in the field of hormone action. The subsequent identification of SRA-binding coregulator proteins, including p68, SHARP and more recently SLIRP, has provided important insight into SRA's mechanism of action and potentially offers new opportunities to target NR signaling pathways for therapeutic gain. Here we outline advances in the field of NR coregulator biology, with a bias on recent progress in understanding SRA-protein interactions. (C) 2008 IUBMB.
    Original languageEnglish
    Pages (from-to)159-164
    JournalIUBMB Life
    Volume60
    Issue number3
    DOIs
    Publication statusPublished - 2008

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