TY - JOUR
T1 - The risk of cerebral palsy in survivors of multiple pregnancies with cofetal loss or death
AU - Taylor, Catherine
AU - De Groot, J.
AU - Blair, Eve
AU - Stanley, Fiona
PY - 2009
Y1 - 2009
N2 - ObjectiveThis study investigated the risks for cerebral palsy in survivors of multiple pregnancies with cofetal loss (<20 weeks' gestation) or cofetal death (≥ 20 weeks' gestation).Study DesignThe total Western Australian population-based case-control study included 741 cases of cerebral palsy.ResultsAntenatal cofetal loss or death occurred in 3% of all cases of cerebral palsy, which is a small but significant contribution. The odds ratio for cerebral palsy in survivors of cofetal loss that included iatrogenic pregnancy reduction was 2.65 (95% confidence interval [CI], 0.78-8.98), which gave a population-attributable proportion of 7.28% (95% CI, 0-27.5), compared with 4.25 (95% CI, 1.12-16.10) and 10.6% (95% CI, 1.0-35.6) for survivors of cofetal death.ConclusionThis study quantifies the contribution of cofetal death to cerebral palsy and suggests that cofetal loss makes a similar, although somewhat smaller, contribution to the risk for cerebral palsy in survivors of multiple pregnancies.
AB - ObjectiveThis study investigated the risks for cerebral palsy in survivors of multiple pregnancies with cofetal loss (<20 weeks' gestation) or cofetal death (≥ 20 weeks' gestation).Study DesignThe total Western Australian population-based case-control study included 741 cases of cerebral palsy.ResultsAntenatal cofetal loss or death occurred in 3% of all cases of cerebral palsy, which is a small but significant contribution. The odds ratio for cerebral palsy in survivors of cofetal loss that included iatrogenic pregnancy reduction was 2.65 (95% confidence interval [CI], 0.78-8.98), which gave a population-attributable proportion of 7.28% (95% CI, 0-27.5), compared with 4.25 (95% CI, 1.12-16.10) and 10.6% (95% CI, 1.0-35.6) for survivors of cofetal death.ConclusionThis study quantifies the contribution of cofetal death to cerebral palsy and suggests that cofetal loss makes a similar, although somewhat smaller, contribution to the risk for cerebral palsy in survivors of multiple pregnancies.
U2 - 10.1016/j.ajog.2009.02.003
DO - 10.1016/j.ajog.2009.02.003
M3 - Article
C2 - 19394587
SN - 0002-9378
VL - 201
SP - 41 e1-6
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -