The Rhythmicity of Body Temperature and its Impact on Clock Gene Expression and Longevity In Vivo

Grace Goh

Research output: ThesisDoctoral Thesis

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Abstract

Circadian rhythms are generated by clock genes, which can be modulated by changes in temperature. This thesis investigated whether body temperature (Tc) influences the amplitude of clock gene expression in vivo, by profiling clock gene expression in peripheral tissues of a novel rodent model of diet-altered Tc, and establishing a link between daily temperature rhythms and lifespan in Drosophila. Additionally, it was statistically determined that episodic ultradian events (EUEs) in Tc are not random fluctuations. The data support a physiological role for Tc rhythms in the circadian system and highlight EUEs as an area of future research.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Maloney, Shane, Supervisor
  • Mark, Peter, Supervisor
  • Blache, Dominique, Supervisor
Thesis sponsors
Award date16 Nov 2022
DOIs
Publication statusUnpublished - 2022

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