The Rhythmicity of Body Temperature and its Impact on Clock Gene Expression and Longevity In Vivo

Grace Goh

doi:10.26182/57js-6519

The Rhythmicity of Body Temperature and its Impact on Clock Gene Expression and Longevity In Vivo

Grace Goh

Research output: Thesis › Doctoral Thesis

150 Downloads (Pure)

Abstract

Circadian rhythms are generated by clock genes, which can be modulated by changes in temperature. This thesis investigated whether body temperature (Tc) influences the amplitude of clock gene expression in vivo, by profiling clock gene expression in peripheral tissues of a novel rodent model of diet-altered Tc, and establishing a link between daily temperature rhythms and lifespan in Drosophila. Additionally, it was statistically determined that episodic ultradian events (EUEs) in Tc are not random fluctuations. The data support a physiological role for Tc rhythms in the circadian system and highlight EUEs as an area of future research.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Maloney, Shane, Supervisor Mark, Peter, Supervisor Blache, Dominique, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	16 Nov 2022
DOIs	https://doi.org/10.26182/57js-6519
Publication status	Unpublished - 2022

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10.26182/57js-6519

THESIS - DOCTOR OF PHILOSOPHY - GOH Grace - 2022
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3 Article
1 Review article

Daily temperature cycles prolong lifespan and have sex-specific effects on peripheral clock gene expression in Drosophila melanogaster
Goh, G. H., Blache, D., Mark, P. J., Jason Kennington, W. & Maloney, S. K., May 2021, In: Journal of Experimental Biology. 224, 10, jeb233213.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Citations (Scopus)
Diet-altered body temperature rhythms are associated with altered rhythms of clock gene expression in peripheral tissues in vivo
Goh, G. H., Mark, P. J., Blache, D., Binks, D., Parsons, R., Rawashdeh, O. & Maloney, S. K., Aug 2021, In: Journal of Thermal Biology. 100, 102983.
Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)
Amplitude of the circadian rhythm of temperature in homeotherms
Maloney, S. K., Goh, G., Fuller, A., Vesterdorf, K. & Blache, D., 1 Jan 2019, In: CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources. 14, 019.
Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus)

Cite this

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title = "The Rhythmicity of Body Temperature and its Impact on Clock Gene Expression and Longevity In Vivo",

abstract = "Circadian rhythms are generated by clock genes, which can be modulated by changes in temperature. This thesis investigated whether body temperature (Tc) influences the amplitude of clock gene expression in vivo, by profiling clock gene expression in peripheral tissues of a novel rodent model of diet-altered Tc, and establishing a link between daily temperature rhythms and lifespan in Drosophila. Additionally, it was statistically determined that episodic ultradian events (EUEs) in Tc are not random fluctuations. The data support a physiological role for Tc rhythms in the circadian system and highlight EUEs as an area of future research.",

keywords = "circadian rhythms, body temperature amplitude, clock gene amplitude, episodic ultradian events, energy balance, Drosophila lifespan, small shuffle surrogate",

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year = "2022",

doi = "10.26182/57js-6519",

language = "English",

school = "The University of Western Australia",

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AB - Circadian rhythms are generated by clock genes, which can be modulated by changes in temperature. This thesis investigated whether body temperature (Tc) influences the amplitude of clock gene expression in vivo, by profiling clock gene expression in peripheral tissues of a novel rodent model of diet-altered Tc, and establishing a link between daily temperature rhythms and lifespan in Drosophila. Additionally, it was statistically determined that episodic ultradian events (EUEs) in Tc are not random fluctuations. The data support a physiological role for Tc rhythms in the circadian system and highlight EUEs as an area of future research.

KW - circadian rhythms

KW - body temperature amplitude

KW - clock gene amplitude

KW - episodic ultradian events

KW - energy balance

KW - Drosophila lifespan

KW - small shuffle surrogate

U2 - 10.26182/57js-6519

DO - 10.26182/57js-6519

M3 - Doctoral Thesis

ER -

The Rhythmicity of Body Temperature and its Impact on Clock Gene Expression and Longevity In Vivo

Abstract

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Research output

Daily temperature cycles prolong lifespan and have sex-specific effects on peripheral clock gene expression in Drosophila melanogaster

Diet-altered body temperature rhythms are associated with altered rhythms of clock gene expression in peripheral tissues in vivo

Amplitude of the circadian rhythm of temperature in homeotherms

Cite this