The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

Qiang Zheng; Ingrid A Cox; Barbara de Graaff; Julie A Campbell; Tamera J Corte; Ian Glaspole; Vidya Navaratnam; Peter Hopkins; Chris Zappala; Hasnat Ahmad; Ting Zhao; Sacha Macansh; E Haydn Walters; Andrew J Palmer

doi:10.1007/s11136-022-03331-8

The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

Qiang Zheng, Ingrid A Cox, Barbara de Graaff, Julie A Campbell, Tamera J Corte, Ian Glaspole, Vidya Navaratnam, Peter Hopkins, Chris Zappala, Hasnat Ahmad, Ting Zhao, Sacha Macansh, E Haydn Walters, Andrew J Palmer

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

PURPOSE: Little is known about the impact of co-morbidities on health-related quality of life (HRQoL) for people with idiopathic pulmonary fibrosis (IPF). We aimed to investigate the relative contribution of co-morbidities to HRQoL of people with IPF.

METHODS: N = 157 participants were recruited from the Australian IPF Registry (AIPFR). Health state utilities (HSUs), and the super-dimensions of physical and psychosocial scores were measured using the Assessment of Quality of Life-8-Dimensions (AQoL-8D). The impact of co-morbidities on HRQoL was investigated using linear regression and general dominance analyses.

RESULTS: A higher number of co-morbidities was associated with lower HSUs (p trend = 0.002). Co-morbidities explained 9.1% of the variance of HSUs, 16.0% of physical super-dimensional scores, and 4.2% of psychosocial super-dimensional scores. Arthritis was associated with a significant reduction on HSUs (β = - 0.09, 95% confidence interval [CI] - 0.16 to - 0.02), largely driven by reduced scores on the physical super-dimension (β = - 0.13, 95% CI - 0.20 to - 0.06). Heart diseases were associated with a significant reduction on HSUs (β = - 0.09, 95% CI - 0.16 to - 0.02), driven by reduced scores on physical (β = - 0.09, 95% CI - 0.16 to - 0.02) and psychosocial (β = -0.10, 95% CI - 0.17 to - 0.02) super-dimensions.

CONCLUSIONS: Co-morbidities significantly impact HRQoL of people with IPF, with markedly negative impacts on their HSUs and physical health. A more holistic approach to the care of people with IPF is important as better management of these co-morbidities could lead to improved HRQoL in people with IPF.

Original language	English
Pages (from-to)	1609-1619
Number of pages	11
Journal	Quality of Life Research
Volume	32
Issue number	6
DOIs	https://doi.org/10.1007/s11136-022-03331-8
Publication status	Published - Jun 2023
Externally published	Yes

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Zheng, Q., Cox, I. A., de Graaff, B., Campbell, J. A., Corte, T. J., Glaspole, I., Navaratnam, V., Hopkins, P., Zappala, C., Ahmad, H., Zhao, T., Macansh, S., Walters, E. H., & Palmer, A. J. (2023). The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument. Quality of Life Research, 32(6), 1609-1619. https://doi.org/10.1007/s11136-022-03331-8

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title = "The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument",

abstract = "PURPOSE: Little is known about the impact of co-morbidities on health-related quality of life (HRQoL) for people with idiopathic pulmonary fibrosis (IPF). We aimed to investigate the relative contribution of co-morbidities to HRQoL of people with IPF.METHODS: N = 157 participants were recruited from the Australian IPF Registry (AIPFR). Health state utilities (HSUs), and the super-dimensions of physical and psychosocial scores were measured using the Assessment of Quality of Life-8-Dimensions (AQoL-8D). The impact of co-morbidities on HRQoL was investigated using linear regression and general dominance analyses.RESULTS: A higher number of co-morbidities was associated with lower HSUs (p trend = 0.002). Co-morbidities explained 9.1% of the variance of HSUs, 16.0% of physical super-dimensional scores, and 4.2% of psychosocial super-dimensional scores. Arthritis was associated with a significant reduction on HSUs (β = - 0.09, 95% confidence interval [CI] - 0.16 to - 0.02), largely driven by reduced scores on the physical super-dimension (β = - 0.13, 95% CI - 0.20 to - 0.06). Heart diseases were associated with a significant reduction on HSUs (β = - 0.09, 95% CI - 0.16 to - 0.02), driven by reduced scores on physical (β = - 0.09, 95% CI - 0.16 to - 0.02) and psychosocial (β = -0.10, 95% CI - 0.17 to - 0.02) super-dimensions.CONCLUSIONS: Co-morbidities significantly impact HRQoL of people with IPF, with markedly negative impacts on their HSUs and physical health. A more holistic approach to the care of people with IPF is important as better management of these co-morbidities could lead to improved HRQoL in people with IPF.",

keywords = "Humans, Quality of Life/psychology, Surveys and Questionnaires, Australia, Idiopathic Pulmonary Fibrosis, Morbidity",

author = "Qiang Zheng and Cox, {Ingrid A} and {de Graaff}, Barbara and Campbell, {Julie A} and Corte, {Tamera J} and Ian Glaspole and Vidya Navaratnam and Peter Hopkins and Chris Zappala and Hasnat Ahmad and Ting Zhao and Sacha Macansh and Walters, {E Haydn} and Palmer, {Andrew J}",

note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.",

year = "2023",

month = jun,

doi = "10.1007/s11136-022-03331-8",

language = "English",

volume = "32",

pages = "1609--1619",

journal = "Quality of Life Research",

issn = "0962-9343",

publisher = "Springer",

number = "6",

}

Zheng, Q, Cox, IA, de Graaff, B, Campbell, JA, Corte, TJ, Glaspole, I, Navaratnam, V, Hopkins, P, Zappala, C, Ahmad, H, Zhao, T, Macansh, S, Walters, EH & Palmer, AJ 2023, 'The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument', Quality of Life Research, vol. 32, no. 6, pp. 1609-1619. https://doi.org/10.1007/s11136-022-03331-8

The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument. / Zheng, Qiang; Cox, Ingrid A; de Graaff, Barbara et al.
In: Quality of Life Research, Vol. 32, No. 6, 06.2023, p. 1609-1619.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

AU - Zheng, Qiang

AU - Cox, Ingrid A

AU - de Graaff, Barbara

AU - Campbell, Julie A

AU - Corte, Tamera J

AU - Glaspole, Ian

AU - Navaratnam, Vidya

AU - Hopkins, Peter

AU - Zappala, Chris

AU - Ahmad, Hasnat

AU - Zhao, Ting

AU - Macansh, Sacha

AU - Walters, E Haydn

AU - Palmer, Andrew J

PY - 2023/6

Y1 - 2023/6

N2 - PURPOSE: Little is known about the impact of co-morbidities on health-related quality of life (HRQoL) for people with idiopathic pulmonary fibrosis (IPF). We aimed to investigate the relative contribution of co-morbidities to HRQoL of people with IPF.METHODS: N = 157 participants were recruited from the Australian IPF Registry (AIPFR). Health state utilities (HSUs), and the super-dimensions of physical and psychosocial scores were measured using the Assessment of Quality of Life-8-Dimensions (AQoL-8D). The impact of co-morbidities on HRQoL was investigated using linear regression and general dominance analyses.RESULTS: A higher number of co-morbidities was associated with lower HSUs (p trend = 0.002). Co-morbidities explained 9.1% of the variance of HSUs, 16.0% of physical super-dimensional scores, and 4.2% of psychosocial super-dimensional scores. Arthritis was associated with a significant reduction on HSUs (β = - 0.09, 95% confidence interval [CI] - 0.16 to - 0.02), largely driven by reduced scores on the physical super-dimension (β = - 0.13, 95% CI - 0.20 to - 0.06). Heart diseases were associated with a significant reduction on HSUs (β = - 0.09, 95% CI - 0.16 to - 0.02), driven by reduced scores on physical (β = - 0.09, 95% CI - 0.16 to - 0.02) and psychosocial (β = -0.10, 95% CI - 0.17 to - 0.02) super-dimensions.CONCLUSIONS: Co-morbidities significantly impact HRQoL of people with IPF, with markedly negative impacts on their HSUs and physical health. A more holistic approach to the care of people with IPF is important as better management of these co-morbidities could lead to improved HRQoL in people with IPF.

AB - PURPOSE: Little is known about the impact of co-morbidities on health-related quality of life (HRQoL) for people with idiopathic pulmonary fibrosis (IPF). We aimed to investigate the relative contribution of co-morbidities to HRQoL of people with IPF.METHODS: N = 157 participants were recruited from the Australian IPF Registry (AIPFR). Health state utilities (HSUs), and the super-dimensions of physical and psychosocial scores were measured using the Assessment of Quality of Life-8-Dimensions (AQoL-8D). The impact of co-morbidities on HRQoL was investigated using linear regression and general dominance analyses.RESULTS: A higher number of co-morbidities was associated with lower HSUs (p trend = 0.002). Co-morbidities explained 9.1% of the variance of HSUs, 16.0% of physical super-dimensional scores, and 4.2% of psychosocial super-dimensional scores. Arthritis was associated with a significant reduction on HSUs (β = - 0.09, 95% confidence interval [CI] - 0.16 to - 0.02), largely driven by reduced scores on the physical super-dimension (β = - 0.13, 95% CI - 0.20 to - 0.06). Heart diseases were associated with a significant reduction on HSUs (β = - 0.09, 95% CI - 0.16 to - 0.02), driven by reduced scores on physical (β = - 0.09, 95% CI - 0.16 to - 0.02) and psychosocial (β = -0.10, 95% CI - 0.17 to - 0.02) super-dimensions.CONCLUSIONS: Co-morbidities significantly impact HRQoL of people with IPF, with markedly negative impacts on their HSUs and physical health. A more holistic approach to the care of people with IPF is important as better management of these co-morbidities could lead to improved HRQoL in people with IPF.

KW - Humans

KW - Quality of Life/psychology

KW - Surveys and Questionnaires

KW - Australia

KW - Idiopathic Pulmonary Fibrosis

KW - Morbidity

U2 - 10.1007/s11136-022-03331-8

DO - 10.1007/s11136-022-03331-8

M3 - Article

C2 - 36572788

SN - 0962-9343

VL - 32

SP - 1609

EP - 1619

JO - Quality of Life Research

JF - Quality of Life Research

IS - 6

ER -