The relationships between cardiovascular disease and diabetes: Focus on pathogenesis

Jason C. Kovacic, Jose M. Castellano, Michael E. Farkouh, Valentin Fuster

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)


There is a looming global epidemic of obesity and diabetes. Of all the end-organ effects caused by diabetes, the cardiovascular system is particularly susceptible to the biologic perturbations caused by this disease, and many patients may die from diabetes-related cardiovascular complications. Substantial progress has been made in understanding the pathobiology of the diabetic vasculature and heart. Clinical studies have illuminated the optimal way to treat patients with cardiovascular manifestations of this disease. This article reviews these aspects of diabetes and the cardiovascular system, broadly classified into diabetic vascular disease, diabetic cardiomyopathy, and the clinical management of the diabetic cardiovascular disease patient.

Original languageEnglish
Pages (from-to)41-57
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
Publication statusPublished - Mar 2014
Externally publishedYes


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