The relationships between cardiovascular disease and diabetes: Focus on pathogenesis

Jason C. Kovacic; Jose M. Castellano; Michael E. Farkouh; Valentin Fuster

doi:10.1016/j.ecl.2013.09.007

The relationships between cardiovascular disease and diabetes: Focus on pathogenesis

Jason C. Kovacic, Jose M. Castellano, Michael E. Farkouh, Valentin Fuster

Research output: Contribution to journal › Review article › peer-review

68 Citations (Scopus)

Abstract

There is a looming global epidemic of obesity and diabetes. Of all the end-organ effects caused by diabetes, the cardiovascular system is particularly susceptible to the biologic perturbations caused by this disease, and many patients may die from diabetes-related cardiovascular complications. Substantial progress has been made in understanding the pathobiology of the diabetic vasculature and heart. Clinical studies have illuminated the optimal way to treat patients with cardiovascular manifestations of this disease. This article reviews these aspects of diabetes and the cardiovascular system, broadly classified into diabetic vascular disease, diabetic cardiomyopathy, and the clinical management of the diabetic cardiovascular disease patient.

Original language	English
Pages (from-to)	41-57
Number of pages	17
Journal	Endocrinology and Metabolism Clinics of North America
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/j.ecl.2013.09.007
Publication status	Published - Mar 2014
Externally published	Yes

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10.1016/j.ecl.2013.09.007

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abstract = "There is a looming global epidemic of obesity and diabetes. Of all the end-organ effects caused by diabetes, the cardiovascular system is particularly susceptible to the biologic perturbations caused by this disease, and many patients may die from diabetes-related cardiovascular complications. Substantial progress has been made in understanding the pathobiology of the diabetic vasculature and heart. Clinical studies have illuminated the optimal way to treat patients with cardiovascular manifestations of this disease. This article reviews these aspects of diabetes and the cardiovascular system, broadly classified into diabetic vascular disease, diabetic cardiomyopathy, and the clinical management of the diabetic cardiovascular disease patient.",

keywords = "Cardiovascular disease, Diabetes, Diabetic cardiomyopathy, Obesity",

author = "Kovacic, {Jason C.} and Castellano, {Jose M.} and Farkouh, {Michael E.} and Valentin Fuster",

note = "Funding Information: No specific funding or grant was used to prepare this article. Jason Kovacic is supported by National Institutes of Health Grant K08HL111330 and has received research support from AstraZeneca . ",

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AU - Castellano, Jose M.

AU - Farkouh, Michael E.

AU - Fuster, Valentin

N1 - Funding Information: No specific funding or grant was used to prepare this article. Jason Kovacic is supported by National Institutes of Health Grant K08HL111330 and has received research support from AstraZeneca .

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KW - Cardiovascular disease

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The relationships between cardiovascular disease and diabetes: Focus on pathogenesis

Abstract

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