The Relationship between Sleep Quality and Brain Amyloid Burden

B.M. Brown, S Rainey-Smith, V.L. Villemagne, Michael Weinborn, Romola Bucks, H.R. Sohrabi, S.M. Laws, K Taddei, L Macaulay, D Ames, C Fowler, P Maruff, C.L. Masters, C.C. Rowe, Ralph Martins

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Study Objectives:

To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found.

Methods:

This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ε4 carriage entered as a moderator.

Results:

Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ (B = 0.003 [standard error = 0.001], P = 0.02). APOE ε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβ burden.

Conclusions:

Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.
Original languageEnglish
Pages (from-to)1063-1068
JournalSLEEP
Volume39
Issue number5
DOIs
Publication statusPublished - 1 May 2016

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Amyloid
Sleep
Brain
Apolipoprotein E4
Alleles
Apolipoproteins E
Neuroimaging
Positron-Emission Tomography
Linear Models
Body Mass Index
Cardiovascular Diseases
Cross-Sectional Studies
Genotype
Regression Analysis
Depression

Cite this

Brown, B. M., Rainey-Smith, S., Villemagne, V. L., Weinborn, M., Bucks, R., Sohrabi, H. R., ... Martins, R. (2016). The Relationship between Sleep Quality and Brain Amyloid Burden. SLEEP, 39(5), 1063-1068. https://doi.org/10.5665/sleep.5756
Brown, B.M. ; Rainey-Smith, S ; Villemagne, V.L. ; Weinborn, Michael ; Bucks, Romola ; Sohrabi, H.R. ; Laws, S.M. ; Taddei, K ; Macaulay, L ; Ames, D ; Fowler, C ; Maruff, P ; Masters, C.L. ; Rowe, C.C. ; Martins, Ralph. / The Relationship between Sleep Quality and Brain Amyloid Burden. In: SLEEP. 2016 ; Vol. 39, No. 5. pp. 1063-1068.
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Brown, BM, Rainey-Smith, S, Villemagne, VL, Weinborn, M, Bucks, R, Sohrabi, HR, Laws, SM, Taddei, K, Macaulay, L, Ames, D, Fowler, C, Maruff, P, Masters, CL, Rowe, CC & Martins, R 2016, 'The Relationship between Sleep Quality and Brain Amyloid Burden' SLEEP, vol. 39, no. 5, pp. 1063-1068. https://doi.org/10.5665/sleep.5756

The Relationship between Sleep Quality and Brain Amyloid Burden. / Brown, B.M.; Rainey-Smith, S; Villemagne, V.L.; Weinborn, Michael; Bucks, Romola; Sohrabi, H.R.; Laws, S.M.; Taddei, K; Macaulay, L; Ames, D; Fowler, C; Maruff, P; Masters, C.L.; Rowe, C.C.; Martins, Ralph.

In: SLEEP, Vol. 39, No. 5, 01.05.2016, p. 1063-1068.

Research output: Contribution to journalArticle

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T1 - The Relationship between Sleep Quality and Brain Amyloid Burden

AU - Brown, B.M.

AU - Rainey-Smith, S

AU - Villemagne, V.L.

AU - Weinborn, Michael

AU - Bucks, Romola

AU - Sohrabi, H.R.

AU - Laws, S.M.

AU - Taddei, K

AU - Macaulay, L

AU - Ames, D

AU - Fowler, C

AU - Maruff, P

AU - Masters, C.L.

AU - Rowe, C.C.

AU - Martins, Ralph

PY - 2016/5/1

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N2 - Study Objectives:To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found.Methods:This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ε4 carriage entered as a moderator.Results:Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ (B = 0.003 [standard error = 0.001], P = 0.02). APOE ε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβ burden.Conclusions:Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.

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DO - 10.5665/sleep.5756

M3 - Article

VL - 39

SP - 1063

EP - 1068

JO - SLEEP

JF - SLEEP

SN - 1179-1608

IS - 5

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Brown BM, Rainey-Smith S, Villemagne VL, Weinborn M, Bucks R, Sohrabi HR et al. The Relationship between Sleep Quality and Brain Amyloid Burden. SLEEP. 2016 May 1;39(5):1063-1068. https://doi.org/10.5665/sleep.5756