The relationship between pulse pressure and inflammation with left ventricular diastolic dysfunction in chronic kidney disease patients

Kenneth Yong; Trevor Mori; Gerard Chew; Lawrence J Beilin; Ian Puddey; Gerald Watts; Gursharan Dogra; Neil Boudville; Wai Lim

doi:10.1111/imj.14037

The relationship between pulse pressure and inflammation with left ventricular diastolic dysfunction in chronic kidney disease patients

Kenneth Yong, Trevor Mori, Gerard Chew, Lawrence J Beilin, Ian Puddey, Gerald Watts, Gursharan Dogra, Neil Boudville, Wai Lim

UWA Medical School

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

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Abstract

INTRODUCTION: Diastolic dysfunction (DD) is an important cause of cardiovascular disease (CVD) mortality in chronic kidney disease (CKD) patients. Non-traditional risk factors such as arterial stiffness and inflammation are implicated in the pathogenesis of DD in CKD patients.

AIM: To determine the association between inflammatory markers [interleukin(IL)-12, IL-18, highly sensitive C-reactive protein (hsCRP)] and non-invasive markers of arterial stiffness [24-hour pulse pressure (PP)] with DD in stage 3-4 CKD patients.

METHODS: We performed a sub-analysis of 78 non-diabetic stage 3-4 CKD subjects to determine the relationship between 24-hour PP, IL-12, IL-18 and hsCRP with DD.

RESULTS: DD was present in 38 subjects (49%). Subjects with DD were significantly older (61.0±1.9 vs 50.2±2.0years; p<0.001) and had higher 24-hour PP [48(95%CI 45, 52) vs 43(95%CI 41, 45)mmHg; p<0.005]. 24-hour PP was associated with DD (p=0.02) but this was no longer significant after adjustment for age (p=0.31). Serum IL-12, IL-18 and hsCRP levels were not significantly different between subjects with or without DD.

CONCLUSION: Asymptomatic subclinical DD was present in 50% of a cohort of stage 3-4 CKD patients but was not associated with IL-12, IL-18 or hsCRP. The association between 24-hour PP and DD was no longer apparent following adjustment for age but given the small sample size our findings will need to be explored in larger sized cohorts of individuals with moderate stage CKD. This article is protected by copyright. All rights reserved.

Original language	English
Pages (from-to)	240-247
Number of pages	8
Journal	Internal Medicine Journal
Volume	49
Issue number	2
DOIs	https://doi.org/10.1111/imj.14037
Publication status	Published - 12 Feb 2019

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10.1111/imj.14037

Yong et al 2019 The relationship between pulse pressure and inflammation
This is the peer reviewed version of the following article: Yong, K. , Mori, T. , Chew, G. , Beilin, L. J., Puddey, I. , Watts, G. , Dogra, G. , Boudville, N. and Lim, W. (2019), The relationship between pulse pressure and inflammation with left ventricular diastolic dysfunction in chronic kidney disease patients, which has been published in final form at https://doi.org/10.1111/imj.14037. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Accepted author manuscript, 914 KB

Effects of Omega-3 fatty Acids and Coenzyme Q10 on Cardiovascular Risk in Chronic Renal Failure
Mori, T. (Chief Investigator), Watts, G. (Chief Investigator), Puddey, I. (Chief Investigator), Irish, A. (Chief Investigator) & Beilin, L. (Chief Investigator)
NHMRC Project Grants
1/01/04 → 31/12/06
Project: Research

Cite this

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title = "The relationship between pulse pressure and inflammation with left ventricular diastolic dysfunction in chronic kidney disease patients",

abstract = "INTRODUCTION: Diastolic dysfunction (DD) is an important cause of cardiovascular disease (CVD) mortality in chronic kidney disease (CKD) patients. Non-traditional risk factors such as arterial stiffness and inflammation are implicated in the pathogenesis of DD in CKD patients.AIM: To determine the association between inflammatory markers [interleukin(IL)-12, IL-18, highly sensitive C-reactive protein (hsCRP)] and non-invasive markers of arterial stiffness [24-hour pulse pressure (PP)] with DD in stage 3-4 CKD patients.METHODS: We performed a sub-analysis of 78 non-diabetic stage 3-4 CKD subjects to determine the relationship between 24-hour PP, IL-12, IL-18 and hsCRP with DD.RESULTS: DD was present in 38 subjects (49%). Subjects with DD were significantly older (61.0±1.9 vs 50.2±2.0years; p<0.001) and had higher 24-hour PP [48(95%CI 45, 52) vs 43(95%CI 41, 45)mmHg; p<0.005]. 24-hour PP was associated with DD (p=0.02) but this was no longer significant after adjustment for age (p=0.31). Serum IL-12, IL-18 and hsCRP levels were not significantly different between subjects with or without DD.CONCLUSION: Asymptomatic subclinical DD was present in 50% of a cohort of stage 3-4 CKD patients but was not associated with IL-12, IL-18 or hsCRP. The association between 24-hour PP and DD was no longer apparent following adjustment for age but given the small sample size our findings will need to be explored in larger sized cohorts of individuals with moderate stage CKD. This article is protected by copyright. All rights reserved.",

author = "Kenneth Yong and Trevor Mori and Gerard Chew and Beilin, {Lawrence J} and Ian Puddey and Gerald Watts and Gursharan Dogra and Neil Boudville and Wai Lim",

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AU - Beilin, Lawrence J

AU - Puddey, Ian

AU - Watts, Gerald

AU - Dogra, Gursharan

AU - Boudville, Neil

AU - Lim, Wai

PY - 2019/2/12

Y1 - 2019/2/12

N2 - INTRODUCTION: Diastolic dysfunction (DD) is an important cause of cardiovascular disease (CVD) mortality in chronic kidney disease (CKD) patients. Non-traditional risk factors such as arterial stiffness and inflammation are implicated in the pathogenesis of DD in CKD patients.AIM: To determine the association between inflammatory markers [interleukin(IL)-12, IL-18, highly sensitive C-reactive protein (hsCRP)] and non-invasive markers of arterial stiffness [24-hour pulse pressure (PP)] with DD in stage 3-4 CKD patients.METHODS: We performed a sub-analysis of 78 non-diabetic stage 3-4 CKD subjects to determine the relationship between 24-hour PP, IL-12, IL-18 and hsCRP with DD.RESULTS: DD was present in 38 subjects (49%). Subjects with DD were significantly older (61.0±1.9 vs 50.2±2.0years; p<0.001) and had higher 24-hour PP [48(95%CI 45, 52) vs 43(95%CI 41, 45)mmHg; p<0.005]. 24-hour PP was associated with DD (p=0.02) but this was no longer significant after adjustment for age (p=0.31). Serum IL-12, IL-18 and hsCRP levels were not significantly different between subjects with or without DD.CONCLUSION: Asymptomatic subclinical DD was present in 50% of a cohort of stage 3-4 CKD patients but was not associated with IL-12, IL-18 or hsCRP. The association between 24-hour PP and DD was no longer apparent following adjustment for age but given the small sample size our findings will need to be explored in larger sized cohorts of individuals with moderate stage CKD. This article is protected by copyright. All rights reserved.

AB - INTRODUCTION: Diastolic dysfunction (DD) is an important cause of cardiovascular disease (CVD) mortality in chronic kidney disease (CKD) patients. Non-traditional risk factors such as arterial stiffness and inflammation are implicated in the pathogenesis of DD in CKD patients.AIM: To determine the association between inflammatory markers [interleukin(IL)-12, IL-18, highly sensitive C-reactive protein (hsCRP)] and non-invasive markers of arterial stiffness [24-hour pulse pressure (PP)] with DD in stage 3-4 CKD patients.METHODS: We performed a sub-analysis of 78 non-diabetic stage 3-4 CKD subjects to determine the relationship between 24-hour PP, IL-12, IL-18 and hsCRP with DD.RESULTS: DD was present in 38 subjects (49%). Subjects with DD were significantly older (61.0±1.9 vs 50.2±2.0years; p<0.001) and had higher 24-hour PP [48(95%CI 45, 52) vs 43(95%CI 41, 45)mmHg; p<0.005]. 24-hour PP was associated with DD (p=0.02) but this was no longer significant after adjustment for age (p=0.31). Serum IL-12, IL-18 and hsCRP levels were not significantly different between subjects with or without DD.CONCLUSION: Asymptomatic subclinical DD was present in 50% of a cohort of stage 3-4 CKD patients but was not associated with IL-12, IL-18 or hsCRP. The association between 24-hour PP and DD was no longer apparent following adjustment for age but given the small sample size our findings will need to be explored in larger sized cohorts of individuals with moderate stage CKD. This article is protected by copyright. All rights reserved.

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JO - Internal Medicine Journal

JF - Internal Medicine Journal

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The relationship between pulse pressure and inflammation with left ventricular diastolic dysfunction in chronic kidney disease patients

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Effects of Omega-3 fatty Acids and Coenzyme Q10 on Cardiovascular Risk in Chronic Renal Failure

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