The Relationship Between Pro-Atherogenic T-Helper-1 Cytokines And Cardiovascular Disease In Chronic Kidney Disease

Kenneth Yong

Research output: ThesisDoctoral Thesis

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Abstract

Chronic kidney disease (CKD) patients have increased risk of cardiovascular disease (CVD). Interleukins(IL)-12 and IL-18 are pro-atherogenic cytokines which are elevated in CKD patients and may contribute to CVD in CKD.
The principal hypothesis of this thesis is that chronic inflammation contributes to increased CVD risk in CKD patients, in part due to elevated levels of IL-12 and IL-18. Therefore, interventions which modify inflammation and reduce IL-12 and IL-18 such as immunosuppression, dialysis modality and ¿3FA supplementation may lead to improvements in surrogate CVD markers including arterial stiffness and LVDD. This thesis consists of six studies which test this hypothesis.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lim, Wai, Supervisor
  • Boudville, Neil, Supervisor
  • Dogra, Gursharan, Supervisor
  • Jeffrey, Gary, Supervisor
Thesis sponsors
Award date4 May 2020
DOIs
Publication statusUnpublished - 2020

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