The relationship between optic disc parameters and female reproductive factors in young women

Samantha S.Y. Lee, Seyhan Yazar, Louis R. Pasquale, Paul G. Sanfilippo, Alex W. Hewitt, Martha Hickey, Rachel Skinner, David A. Mackey

Research output: Contribution to journalArticle

Abstract

Purpose: It has been suggested that female sex steroids have neuroprotective properties that may reduce risk of glaucoma in premenopausal women. In this study, we explored the associations of optic disc measures with female reproductive factors in a population of young women. Design: Cohort study. Methods: Young women (n = 494; age range, 18–22 years) were recruited as part of the Western Australian Pregnancy Cohort (Raine) Study. Information on age at menarche, parity, and use of hormonal contraceptives were obtained from questionnaires. Participants underwent an eye examination, including spectral-domain optical coherence tomography imaging, to obtain optic disc parameters. Results: Women who had given birth at least once (parous women; n = 10) had larger vertical neuroretinal rim widths (P < 0.001) than nulliparous women (n = 484) after correcting for use of hormonal contraceptives, intraocular pressure, refractive error, and family history of glaucoma. Furthermore, vertical and horizontal cup-to-disc ratios, which are inherently related to neuroretinal rim width, were found to be smaller among parous women compared with nulliparous women (both P < 0.001). Age at menarche and use of hormonal contraceptives were not significantly associated with any optic disc parameters. Conclusions: We found limited evidence that female reproductive factors were related with optic disc parameters during young adulthood. The association between parity and optic disc parameter, though significant, should be further investigated given the small number of parous women in the current sample. Future follow-ups of this cohort will allow us to explore any associations of these factors with optic disc parameters and glaucoma risk at an older age.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalAsia-Pacific Journal of Ophthalmology
Volume8
Issue number3
DOIs
Publication statusPublished - May 2019

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Optic Disk
Contraceptive Agents
Glaucoma
Menarche
Parity
Cohort Studies
Refractive Errors
Optical Coherence Tomography
Intraocular Pressure
Steroids
Parturition
Pregnancy

Cite this

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title = "The relationship between optic disc parameters and female reproductive factors in young women",
abstract = "Purpose: It has been suggested that female sex steroids have neuroprotective properties that may reduce risk of glaucoma in premenopausal women. In this study, we explored the associations of optic disc measures with female reproductive factors in a population of young women. Design: Cohort study. Methods: Young women (n = 494; age range, 18–22 years) were recruited as part of the Western Australian Pregnancy Cohort (Raine) Study. Information on age at menarche, parity, and use of hormonal contraceptives were obtained from questionnaires. Participants underwent an eye examination, including spectral-domain optical coherence tomography imaging, to obtain optic disc parameters. Results: Women who had given birth at least once (parous women; n = 10) had larger vertical neuroretinal rim widths (P < 0.001) than nulliparous women (n = 484) after correcting for use of hormonal contraceptives, intraocular pressure, refractive error, and family history of glaucoma. Furthermore, vertical and horizontal cup-to-disc ratios, which are inherently related to neuroretinal rim width, were found to be smaller among parous women compared with nulliparous women (both P < 0.001). Age at menarche and use of hormonal contraceptives were not significantly associated with any optic disc parameters. Conclusions: We found limited evidence that female reproductive factors were related with optic disc parameters during young adulthood. The association between parity and optic disc parameter, though significant, should be further investigated given the small number of parous women in the current sample. Future follow-ups of this cohort will allow us to explore any associations of these factors with optic disc parameters and glaucoma risk at an older age.",
keywords = "Female reproductive factors, Glaucoma, Oestrogens, Optic disc, Raine Study",
author = "Lee, {Samantha S.Y.} and Seyhan Yazar and Pasquale, {Louis R.} and Sanfilippo, {Paul G.} and Hewitt, {Alex W.} and Martha Hickey and Rachel Skinner and Mackey, {David A.}",
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The relationship between optic disc parameters and female reproductive factors in young women. / Lee, Samantha S.Y.; Yazar, Seyhan; Pasquale, Louis R.; Sanfilippo, Paul G.; Hewitt, Alex W.; Hickey, Martha; Skinner, Rachel; Mackey, David A.

In: Asia-Pacific Journal of Ophthalmology, Vol. 8, No. 3, 05.2019, p. 224-228.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The relationship between optic disc parameters and female reproductive factors in young women

AU - Lee, Samantha S.Y.

AU - Yazar, Seyhan

AU - Pasquale, Louis R.

AU - Sanfilippo, Paul G.

AU - Hewitt, Alex W.

AU - Hickey, Martha

AU - Skinner, Rachel

AU - Mackey, David A.

PY - 2019/5

Y1 - 2019/5

N2 - Purpose: It has been suggested that female sex steroids have neuroprotective properties that may reduce risk of glaucoma in premenopausal women. In this study, we explored the associations of optic disc measures with female reproductive factors in a population of young women. Design: Cohort study. Methods: Young women (n = 494; age range, 18–22 years) were recruited as part of the Western Australian Pregnancy Cohort (Raine) Study. Information on age at menarche, parity, and use of hormonal contraceptives were obtained from questionnaires. Participants underwent an eye examination, including spectral-domain optical coherence tomography imaging, to obtain optic disc parameters. Results: Women who had given birth at least once (parous women; n = 10) had larger vertical neuroretinal rim widths (P < 0.001) than nulliparous women (n = 484) after correcting for use of hormonal contraceptives, intraocular pressure, refractive error, and family history of glaucoma. Furthermore, vertical and horizontal cup-to-disc ratios, which are inherently related to neuroretinal rim width, were found to be smaller among parous women compared with nulliparous women (both P < 0.001). Age at menarche and use of hormonal contraceptives were not significantly associated with any optic disc parameters. Conclusions: We found limited evidence that female reproductive factors were related with optic disc parameters during young adulthood. The association between parity and optic disc parameter, though significant, should be further investigated given the small number of parous women in the current sample. Future follow-ups of this cohort will allow us to explore any associations of these factors with optic disc parameters and glaucoma risk at an older age.

AB - Purpose: It has been suggested that female sex steroids have neuroprotective properties that may reduce risk of glaucoma in premenopausal women. In this study, we explored the associations of optic disc measures with female reproductive factors in a population of young women. Design: Cohort study. Methods: Young women (n = 494; age range, 18–22 years) were recruited as part of the Western Australian Pregnancy Cohort (Raine) Study. Information on age at menarche, parity, and use of hormonal contraceptives were obtained from questionnaires. Participants underwent an eye examination, including spectral-domain optical coherence tomography imaging, to obtain optic disc parameters. Results: Women who had given birth at least once (parous women; n = 10) had larger vertical neuroretinal rim widths (P < 0.001) than nulliparous women (n = 484) after correcting for use of hormonal contraceptives, intraocular pressure, refractive error, and family history of glaucoma. Furthermore, vertical and horizontal cup-to-disc ratios, which are inherently related to neuroretinal rim width, were found to be smaller among parous women compared with nulliparous women (both P < 0.001). Age at menarche and use of hormonal contraceptives were not significantly associated with any optic disc parameters. Conclusions: We found limited evidence that female reproductive factors were related with optic disc parameters during young adulthood. The association between parity and optic disc parameter, though significant, should be further investigated given the small number of parous women in the current sample. Future follow-ups of this cohort will allow us to explore any associations of these factors with optic disc parameters and glaucoma risk at an older age.

KW - Female reproductive factors

KW - Glaucoma

KW - Oestrogens

KW - Optic disc

KW - Raine Study

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U2 - 10.22608/APO.2018329

DO - 10.22608/APO.2018329

M3 - Article

VL - 8

SP - 224

EP - 228

JO - Asia Pacific Journal of Opthalmology

JF - Asia Pacific Journal of Opthalmology

SN - 2162-0989

IS - 3

ER -