The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies

Jason Wee; Sara Sukudom; Saiuj Bhat; Matti Marklund; Niridu Jude Peiris; Camilla M. Hoyos; Sanjay Patel; Sharon L. Naismith; Girish Dwivedi; Ashish Misra

doi:10.1002/dad2.12395

The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies

Jason Wee, Sara Sukudom, Saiuj Bhat, Matti Marklund, Niridu Jude Peiris, Camilla M. Hoyos, Sanjay Patel, Sharon L. Naismith, Girish Dwivedi, Ashish Misra

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28 Citations (Scopus)

Abstract

Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia. Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis. Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I² = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I² = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I² = 0.3%) in incidence of all-cause dementia. Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.

Original language	English
Article number	e12395
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	15
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12395
Publication status	Published - 1 Jan 2023

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Wee, J., Sukudom, S., Bhat, S., Marklund, M., Peiris, N. J., Hoyos, C. M., Patel, S., Naismith, S. L., Dwivedi, G., & Misra, A. (2023). The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15(1), Article e12395. https://doi.org/10.1002/dad2.12395

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title = "The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies",

abstract = "Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia. Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis. Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I2 = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I2 = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I2 = 0.3%) in incidence of all-cause dementia. Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.",

keywords = "aging, cholesterol, cognitive, cognitive dysfunction, dementia, dyslipidemia, midlife",

author = "Jason Wee and Sara Sukudom and Saiuj Bhat and Matti Marklund and Peiris, {Niridu Jude} and Hoyos, {Camilla M.} and Sanjay Patel and Naismith, {Sharon L.} and Girish Dwivedi and Ashish Misra",

note = "Funding Information: The authors would like to thank the authors of included studies who provided us with supplementary data. Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",

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Wee, J, Sukudom, S, Bhat, S, Marklund, M, Peiris, NJ, Hoyos, CM, Patel, S, Naismith, SL, Dwivedi, G & Misra, A 2023, 'The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 15, no. 1, e12395. https://doi.org/10.1002/dad2.12395

TY - JOUR

T1 - The relationship between midlife dyslipidemia and lifetime incidence of dementia

T2 - A systematic review and meta-analysis of cohort studies

AU - Wee, Jason

AU - Sukudom, Sara

AU - Bhat, Saiuj

AU - Marklund, Matti

AU - Peiris, Niridu Jude

AU - Hoyos, Camilla M.

AU - Patel, Sanjay

AU - Naismith, Sharon L.

AU - Dwivedi, Girish

AU - Misra, Ashish

N1 - Funding Information: The authors would like to thank the authors of included studies who provided us with supplementary data. Publisher Copyright: © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia. Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis. Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I2 = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I2 = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I2 = 0.3%) in incidence of all-cause dementia. Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.

AB - Introduction: We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia. Methods: The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis. Results: Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; I2 = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; I2 = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I2 = 0.3%) in incidence of all-cause dementia. Discussion: Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.

KW - aging

KW - cholesterol

KW - cognitive

KW - cognitive dysfunction

KW - dementia

KW - dyslipidemia

KW - midlife

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U2 - 10.1002/dad2.12395

DO - 10.1002/dad2.12395

M3 - Article

C2 - 36911359

AN - SCOPUS:85151688636

SN - 2352-8729

VL - 15

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

M1 - e12395

ER -

The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies

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