The relationship between lifestyle and serum neurofilament light protein in Huntington’s disease

Travis Cruickshank, Danielle Bartlett, Andrew Govus, Anthony Hannan, Wei Peng Teo, Sarah Mason, Johnny Lo, Mel Ziman

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Objectives: Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age- and sex-matched controls. Materials and Methods: Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model. Results: Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group × lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity. Conclusion: These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.

    Original languageEnglish
    Article numbere01578
    JournalBrain and Behavior
    Volume10
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2020

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