The relationship between lifestyle and serum neurofilament light protein in Huntington’s disease

Travis Cruickshank; Danielle Bartlett; Andrew Govus; Anthony Hannan; Wei Peng Teo; Sarah Mason; Johnny Lo; Mel Ziman

doi:10.1002/brb3.1578

The relationship between lifestyle and serum neurofilament light protein in Huntington’s disease

Travis Cruickshank, Danielle Bartlett, Andrew Govus, Anthony Hannan, Wei Peng Teo, Sarah Mason, Johnny Lo, Mel Ziman

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Objectives: Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age- and sex-matched controls. Materials and Methods: Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model. Results: Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group × lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity. Conclusion: These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.

Original language	English
Article number	e01578
Journal	Brain and Behavior
Volume	10
Issue number	5
DOIs	https://doi.org/10.1002/brb3.1578
Publication status	Published - 1 May 2020

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10.1002/brb3.1578Licence: CC BY

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title = "The relationship between lifestyle and serum neurofilament light protein in Huntington{\textquoteright}s disease",

abstract = "Objectives: Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age- and sex-matched controls. Materials and Methods: Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model. Results: Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group × lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity. Conclusion: These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.",

keywords = "cardiorespiratory fitness, cognitive reserve, lifestyle, neurofilament light protein, social network",

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AU - Cruickshank, Travis

AU - Bartlett, Danielle

AU - Govus, Andrew

AU - Hannan, Anthony

AU - Teo, Wei Peng

AU - Mason, Sarah

AU - Lo, Johnny

AU - Ziman, Mel

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Objectives: Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age- and sex-matched controls. Materials and Methods: Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model. Results: Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group × lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity. Conclusion: These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.

AB - Objectives: Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age- and sex-matched controls. Materials and Methods: Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model. Results: Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group × lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity. Conclusion: These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.

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KW - cognitive reserve

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The relationship between lifestyle and serum neurofilament light protein in Huntington’s disease

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