Projects per year
Abstract
BACKGROUND: Previous studies have reported an association between low birthweight and elevated blood pressure (BP) in adulthood, but few have examined the relationship between foetal growth and adult BP. METHOD: The study examined the association between intrauterine growth trajectories determined by serial ultrasound and BP of the adult offspring in the Raine Study. Foetal growth trajectories for abdominal circumference, femur length and head circumference z-scores were developed using group-based trajectory modelling from 1440 women with serial ultrasounds from 15-weeks pregnancy to birth. Seven abdominal circumference, five femur length and five head circumference trajectory groups were identified. Longitudinal linear mixed modelling examined the association between trajectory groups and offspring BP at 20 (n = 487), 22 (n = 419) and 27 (n = 436) years. RESULTS: Higher SBP in adulthood significantly associated with two abdominal circumference trajectories, one with the most restricted foetal growth [3.52 mmHg, 95% confidence interval (95% CI) = 1.20-5.83] and the other with sustained low-growth (1.92 mmHg, 95% CI = 0.11-3.73) compared with an average growth trajectory, after adjusting for sex, age, alcohol consumption and BMI. Foetal head circumference trajectories with sustained low-growth or average-to-falling growth significantly associated with higher adult systolic (3.45 mmHg, 95% CI = 1.77-5.14 and 1.54 mmHg, 95% CI = 0.30-2.78, respectively) and diastolic (2.28 mmHg, 95% CI = 0.77-3.78 and 1.47 mmHg, 95% CI = 0.54-2.39, respectively) BP compared with average growth. Low femur length growth associated with higher adult DBP after adjusting for sex, but not after accounting for adult BMI. CONCLUSION: Our results show that restricted foetal head and abdominal circumference associated with higher adult SBP over two decades later, reinforcing the importance of the early intrauterine environment and its influence on adult BP.
Original language | English |
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Pages (from-to) | 478-489 |
Number of pages | 12 |
Journal | Journal of Hypertension |
Volume | 40 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Mar 2022 |
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Investigating the mechanisms and preventative strategies to alleviate the burden of cardiovascular disease
Mori, T. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/18 → 31/12/22
Project: Research
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Genetic And Early Life Predictors Of Ectopic Fat And Their Association With Cardiometabolic Health And Disease
Mori, T. (Investigator 01), Beilin, L. (Investigator 02), Moses, E. (Investigator 03), Watts, G. (Investigator 04) & Adams, L. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/16 → 31/12/22
Project: Research
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Rae-Chi Huang - Early Life Programming of Cardiovascular Disease
Huang, R.-C. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/13 → 29/02/20
Project: Research