The reduction potential of the slipped GC base pair in one-electron oxidized duplex DNA

Robert F. Anderson, Sujata Shinde, Andrej Maroz, Jóhannes Reynisson

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Redox equilibrium between the low potential aniline radical cation and the guanine in the GC base pair of duplex DNA has been established using pulse radiolysis. We relate the measurement of a radical one electron reduction potential, E00, of 1.01 0.03 V to the perturbation of the GC base pair to accommodate the neutral guanyl radical in an energetically more stable ‘slipped’ structure. The formation of the ‘slipped’ structure is exothermic by 11.4 kcal mol1 as calculated by DFT, which is inline with our experimental results.
Original languageEnglish
Article numberDOI: 10.1039/c9cp05544d
Pages (from-to)642-646
JournalPhysical Chemistry Chemical Physics
Volume22
Issue number2
Publication statusPublished - 2020
Externally publishedYes

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