The rediscovery of methadone for cancer pain management

O. T. Ayonrinde, D. T. Bridge

Research output: Contribution to journalReview articlepeer-review

76 Citations (Scopus)


Methadone is a potent synthetic opioid analgesic best known in Australia as maintenance therapy for narcotic addicts. Acceptance of methadone in cancer pain management is limited by a poor understanding of its pharmacokinetics and confusion about dosage. Many opioid conversion charts underestimate the potency of methadone, resulting in the risk of toxicity. Methadone is a valuable addition to the armamentarium of clinicians treating severe cancer pain, particularly neuropathic pain, that is poorly responsive to opioids or where opioid side effects are unacceptable.

Original languageEnglish
Pages (from-to)536-540
Number of pages5
JournalMedical Journal of Australia
Issue number10
Publication statusPublished - 20 Nov 2000
Externally publishedYes


Dive into the research topics of 'The rediscovery of methadone for cancer pain management'. Together they form a unique fingerprint.

Cite this