TY - JOUR
T1 - The rare and undiagnosed diseases diagnostic service - application of massively parallel sequencing in a state-wide clinical service
AU - Baynam, Gareth
AU - Pachter, Nicholas
AU - McKenzie, Fiona
AU - Townshend, S.
AU - Slee, J.
AU - Kiraly-Borri, C.
AU - Vasudevan, A.
AU - Hawkins, A.
AU - Broley, S.
AU - Schofield, L.
AU - Verhoef, H.
AU - Walker, C. E. E.
AU - Molster, C.
AU - Blackwell, Jenefer M.
AU - Jamieson, Sarra
AU - Tang, Dave
AU - Lassmann, Timo
AU - Mina, Kym
AU - Beilby, John
AU - Davis, Mark
AU - Laing, Nigel
AU - Murphy, L.
AU - Weeramanthri, T.
AU - Dawkins, Hugh
AU - Goldblatt, Jack
N1 - Funding Information:
GB was supported by the Raine Clinical Research Fellowship; NL was supported by the Australian Medical Research Council Fellowship (APP1002147) and Centre for Research Excellence Grant (APP1031893).
Publisher Copyright:
© 2016 The Author(s).
PY - 2016/6/11
Y1 - 2016/6/11
N2 - Background: The Rare and Undiagnosed Diseases Diagnostic Service (RUDDS) refers to a genomic diagnostic platform operating within the Western Australian Government clinical services delivered through Genetic Services of Western Australia (GSWA). GSWA has provided a state-wide service for clinical genetic care for 28 years and it serves a population of 2.5 million people across a geographical area of 2.5milion Km(2). Within this context, GSWA has established a clinically integrated genomic diagnostic platform in partnership with other public health system managers and service providers, including but not limited to the Office of Population Health Genomics, Diagnostic Genomics (PathWest Laboratories) and with executive level support from the Department of Health. Herein we describe report presents the components of this service that are most relevant to the heterogeneity of paediatric clinical genetic care.Results: Briefly the platform : i) offers multiple options including non-genetic testing; monogenic and genomic (targeted in silico filtered and whole exome) analysis; and matchmaking; ii) is delivered in a patient-centric manner that is resonant with the patient journey, it has multiple points for entry, exit and re-entry to allow people access to information they can use, when they want to receive it; iii) is synchronous with precision phenotyping methods; iv) captures new knowledge, including multiple expert review; v) is integrated with current translational genomic research activities and best practice; and vi) is designed for flexibility for interactive generation of, and integration with, clinical research for diagnostics, community engagement, policy and models of care.Conclusion: The RUDDS has been established as part of routine clinical genetic services and is thus sustainable, equitably managed and seeks to translate new knowledge into efficient diagnostics and improved health for the whole community.
AB - Background: The Rare and Undiagnosed Diseases Diagnostic Service (RUDDS) refers to a genomic diagnostic platform operating within the Western Australian Government clinical services delivered through Genetic Services of Western Australia (GSWA). GSWA has provided a state-wide service for clinical genetic care for 28 years and it serves a population of 2.5 million people across a geographical area of 2.5milion Km(2). Within this context, GSWA has established a clinically integrated genomic diagnostic platform in partnership with other public health system managers and service providers, including but not limited to the Office of Population Health Genomics, Diagnostic Genomics (PathWest Laboratories) and with executive level support from the Department of Health. Herein we describe report presents the components of this service that are most relevant to the heterogeneity of paediatric clinical genetic care.Results: Briefly the platform : i) offers multiple options including non-genetic testing; monogenic and genomic (targeted in silico filtered and whole exome) analysis; and matchmaking; ii) is delivered in a patient-centric manner that is resonant with the patient journey, it has multiple points for entry, exit and re-entry to allow people access to information they can use, when they want to receive it; iii) is synchronous with precision phenotyping methods; iv) captures new knowledge, including multiple expert review; v) is integrated with current translational genomic research activities and best practice; and vi) is designed for flexibility for interactive generation of, and integration with, clinical research for diagnostics, community engagement, policy and models of care.Conclusion: The RUDDS has been established as part of routine clinical genetic services and is thus sustainable, equitably managed and seeks to translate new knowledge into efficient diagnostics and improved health for the whole community.
KW - Clinical best practice
KW - Diagnosis
KW - Diagnostic odyssey
KW - Genomics
KW - Policy
KW - Precision public health
KW - Undiagnosed
UR - http://www.scopus.com/inward/record.url?scp=84976892784&partnerID=8YFLogxK
U2 - 10.1186/s13023-016-0462-7
DO - 10.1186/s13023-016-0462-7
M3 - Article
C2 - 27287197
SN - 1750-1172
VL - 11
JO - Orphanet Journal of Rare Diseases
JF - Orphanet Journal of Rare Diseases
IS - 1
M1 - 77
ER -