The quest for mechanically and biologically functional soft biomaterials via soft network composites

Onur Bas, Isabelle Catelas, Elena M. De-Juan-Pardo, Dietmar W. Hutmacher

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Developing multifunctional soft biomaterials capable of addressing all the requirements of the complex tissue regeneration process is a multifaceted problem. In order to tackle the current challenges, recent research efforts are increasingly being directed towards biomimetic design concepts that can be translated into soft biomaterials via advanced manufacturing technologies. Among those, soft network composites consisting of a continuous hydrogel matrix and a reinforcing fibrous network closely resemble native soft biological materials in terms of design and composition as well as physicochemical properties. This article reviews soft network composite systems with a particular emphasis on the design, biomaterial and fabrication aspects within the context of soft tissue engineering and drug delivery applications.

Original languageEnglish
Pages (from-to)214-234
Number of pages21
JournalAdvanced Drug Delivery Reviews
Volume132
DOIs
Publication statusPublished - Jul 2018
Externally publishedYes

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