The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

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Abstract

The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.

Original languageEnglish
Pages (from-to)12926-12933
Number of pages8
JournalLangmuir
Volume33
Issue number45
DOIs
Publication statusPublished - 14 Nov 2017

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serums
coronas
Blood Proteins
Nanoparticles
proteins
Proteins
nanoparticles
Polyethylene glycols
Protein Corona
polyglycidyl methacrylate
glycols
ethylene
Chemical analysis

Cite this

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title = "The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function",
abstract = "The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.",
author = "Naidu, {Priya S.R.} and Marck Norret and Smith, {Nicole M.} and Dunlop, {Sarah A.} and Taylor, {Nicolas L.} and Melinda Fitzgerald and Iyer, {K. Swaminathan}",
year = "2017",
month = "11",
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doi = "10.1021/acs.langmuir.7b02568",
language = "English",
volume = "33",
pages = "12926--12933",
journal = "Langmuir: the A C S Journal of Surfaces and Colloids",
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TY - JOUR

T1 - The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

AU - Naidu, Priya S.R.

AU - Norret, Marck

AU - Smith, Nicole M.

AU - Dunlop, Sarah A.

AU - Taylor, Nicolas L.

AU - Fitzgerald, Melinda

AU - Iyer, K. Swaminathan

PY - 2017/11/14

Y1 - 2017/11/14

N2 - The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.

AB - The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.

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U2 - 10.1021/acs.langmuir.7b02568

DO - 10.1021/acs.langmuir.7b02568

M3 - Article

VL - 33

SP - 12926

EP - 12933

JO - Langmuir: the A C S Journal of Surfaces and Colloids

JF - Langmuir: the A C S Journal of Surfaces and Colloids

SN - 0743-7463

IS - 45

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