The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

Priya S.R. Naidu; Marck Norret; Nicole M. Smith; Sarah A. Dunlop; Nicolas L. Taylor; Melinda Fitzgerald; K. Swaminathan Iyer

doi:10.1021/acs.langmuir.7b02568

The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

Priya S.R. Naidu, Marck Norret, Nicole M. Smith, Sarah A. Dunlop, Nicolas L. Taylor, Melinda Fitzgerald, K. Swaminathan Iyer

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

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Abstract

The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.

Original language	English
Pages (from-to)	12926-12933
Number of pages	8
Journal	Langmuir
Volume	33
Issue number	45
DOIs	https://doi.org/10.1021/acs.langmuir.7b02568
Publication status	Published - 14 Nov 2017

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10.1021/acs.langmuir.7b02568

Naidu et al., 2017 The protein corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher.
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title = "The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function",

abstract = "The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.",

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AU - Taylor, Nicolas L.

AU - Fitzgerald, Melinda

AU - Iyer, K. Swaminathan

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The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

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Targeted nanoparticles to deliver combinations of calcium channel inhibitors to prevent myelin damage during secondary degeneration after neurotrauma

Innovative and multi-disciplinary treatment strategies for secondary degeneration following neurotrauma

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The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

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Targeted nanoparticles to deliver combinations of calcium channel inhibitors to prevent myelin damage during secondary degeneration after neurotrauma

Innovative and multi-disciplinary treatment strategies for secondary degeneration following neurotrauma

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