TY - JOUR
T1 - The prognosis of heart failure patients
T2 - Does sodium level play a significant role?
AU - Abebe, Tamrat Befekadu
AU - Gebreyohannes, Eyob Alemayehu
AU - Tefera, Yonas Getaye
AU - Bhagavathula, Akshaya Srikanth
AU - Erku, Daniel Asfaw
AU - Belachew, Sewunet Admasu
AU - Gebresillassie, Begashaw Melaku
AU - Abegaz, Tadesse Melaku
PY - 2018/11/8
Y1 - 2018/11/8
N2 - IntroductionHeart failure (HF), a major cardiovascular disorder, remains a grievous clinical condition regardless of advances in medical care. Hyponatremia is classified as a serum sodium concentration ofMethodA retrospective cohort study was conducted to assess medical records of heart failure patients who were admitted to Gondar University Referral Hospital. Patients were categorized based on their sodium level status at their first admission to the internal medicine department. Each patient was assigned to either of the following groups: hyponatremia if sodium <135 mmol/L, or normonatremia if sodium >= 135 mmol/L.ResultAmong 388 participants, the prevalence of hyponatremia in the study cohorts was 51.03%. Kaplan-Meier survival curves showed that there was a significant difference in survival status of HF patients among the two cohorts (Log-Rank test, PConclusionIn conclusion, hyponatremia is one of the crucial factors in the clinical prognosis of heart failure patients. However, as other prognostic factors (i.e. medication, creatine level, and age) also played vital roles in overall survival, well-controlled clinical trials (complete with medication dosing, laboratory outputs and long-term prospective follow up) are required to further study the impact of hyponatremia in HF patient's prognosis in low income nations.
AB - IntroductionHeart failure (HF), a major cardiovascular disorder, remains a grievous clinical condition regardless of advances in medical care. Hyponatremia is classified as a serum sodium concentration ofMethodA retrospective cohort study was conducted to assess medical records of heart failure patients who were admitted to Gondar University Referral Hospital. Patients were categorized based on their sodium level status at their first admission to the internal medicine department. Each patient was assigned to either of the following groups: hyponatremia if sodium <135 mmol/L, or normonatremia if sodium >= 135 mmol/L.ResultAmong 388 participants, the prevalence of hyponatremia in the study cohorts was 51.03%. Kaplan-Meier survival curves showed that there was a significant difference in survival status of HF patients among the two cohorts (Log-Rank test, PConclusionIn conclusion, hyponatremia is one of the crucial factors in the clinical prognosis of heart failure patients. However, as other prognostic factors (i.e. medication, creatine level, and age) also played vital roles in overall survival, well-controlled clinical trials (complete with medication dosing, laboratory outputs and long-term prospective follow up) are required to further study the impact of hyponatremia in HF patient's prognosis in low income nations.
KW - PRESERVED SYSTOLIC FUNCTION
KW - SALINE SOLUTION INFUSION
KW - HIGH-DOSE FUROSEMIDE
KW - SERUM SODIUM
KW - HOSPITALIZED-PATIENTS
KW - CLINICAL CHARACTERISTICS
KW - VASOPRESSIN ANTAGONIST
KW - PREDICTING MORTALITY
KW - SEVERE HYPONATREMIA
KW - EJECTION FRACTION
U2 - 10.1371/journal.pone.0207242
DO - 10.1371/journal.pone.0207242
M3 - Article
VL - 13
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 11
M1 - e0207242
ER -