The prognosis of heart failure patients: Does sodium level play a significant role?

Tamrat Befekadu Abebe, Eyob Alemayehu Gebreyohannes, Yonas Getaye Tefera, Akshaya Srikanth Bhagavathula, Daniel Asfaw Erku, Sewunet Admasu Belachew, Begashaw Melaku Gebresillassie, Tadesse Melaku Abegaz

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10 Citations (Web of Science)



Heart failure (HF), a major cardiovascular disorder, remains a grievous clinical condition regardless of advances in medical care. Hyponatremia is classified as a serum sodium concentration of


A retrospective cohort study was conducted to assess medical records of heart failure patients who were admitted to Gondar University Referral Hospital. Patients were categorized based on their sodium level status at their first admission to the internal medicine department. Each patient was assigned to either of the following groups: hyponatremia if sodium <135 mmol/L, or normonatremia if sodium >= 135 mmol/L.


Among 388 participants, the prevalence of hyponatremia in the study cohorts was 51.03%. Kaplan-Meier survival curves showed that there was a significant difference in survival status of HF patients among the two cohorts (Log-Rank test, P


In conclusion, hyponatremia is one of the crucial factors in the clinical prognosis of heart failure patients. However, as other prognostic factors (i.e. medication, creatine level, and age) also played vital roles in overall survival, well-controlled clinical trials (complete with medication dosing, laboratory outputs and long-term prospective follow up) are required to further study the impact of hyponatremia in HF patient's prognosis in low income nations.

Original languageEnglish
Article numbere0207242
Number of pages14
JournalPLoS One
Issue number11
Publication statusPublished - 8 Nov 2018
Externally publishedYes


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