The present invention relates to methods for preventing, reducing, or treating the incidence and/or severity of a disorder caused by stress-induced cellular damage in the ear of a subject, such as vestibular disorders, hearing impairment, and conditions related to hair cell degeneration or death. Specifically, this invention pertains to formulations comprising probucol or a probucol ester, a bioavailability-enhancing compound comprising a bile acid, and optionally a carrier. The administration of these formulations can treat hearing loss and/or hair cell degeneration or death.

Jafri Kuthubutheen (Inventor), Armin Mooranian (Inventor), Daniel Brown (Inventor), Hani Al-Salami (Inventor)

Research output: Patentpeer-review

Original languageEnglish
Patent numberWO 2021/24810 A1
Publication statusPublished - 2021

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