The potential influence of bone-derived modulators on the progression of Alzheimer's disease

Research output: Contribution to journalReview article

Abstract

Bone, the major structural scaffold of the human body, has recently been demonstrated to interact with several other organ systems through the actions of bone-derived cells and bone-derived cell secretory proteins. Interestingly, the brain is one organ that appears to fall into this interconnected network. Furthermore, the fact that osteoporosis and Alzheimer's disease are two common age-related disorders raises the possibility that these two organ systems are interconnected in terms of disease pathogenesis. This review focuses on the latest evidence demonstrating the impact of bone-derived cells and bone-derived proteins on the central nervous system, and on how this may be relevant in the progression of Alzheimer's disease and for the identification of novel therapeutic approaches to treat this neurodegenerative disorder.

Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalJournal of Alzheimer's Disease
Volume69
Issue number1
DOIs
Publication statusPublished - 7 May 2019

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Alzheimer Disease
Bone and Bones
Human Body
Neurodegenerative Diseases
Osteoporosis
Proteins
Central Nervous System
Brain
Therapeutics

Cite this

@article{e8ede805e8d84c63a9afd4b48105c689,
title = "The potential influence of bone-derived modulators on the progression of Alzheimer's disease",
abstract = "Bone, the major structural scaffold of the human body, has recently been demonstrated to interact with several other organ systems through the actions of bone-derived cells and bone-derived cell secretory proteins. Interestingly, the brain is one organ that appears to fall into this interconnected network. Furthermore, the fact that osteoporosis and Alzheimer's disease are two common age-related disorders raises the possibility that these two organ systems are interconnected in terms of disease pathogenesis. This review focuses on the latest evidence demonstrating the impact of bone-derived cells and bone-derived proteins on the central nervous system, and on how this may be relevant in the progression of Alzheimer's disease and for the identification of novel therapeutic approaches to treat this neurodegenerative disorder.",
keywords = "Alzheimer's disease, bone, mesenchymal stem cells, microglia, osteocalcin",
author = "Jun Yuan and Meloni, {Bruno P.} and Tianxing Shi and Anne Bonser and Papadimitriou, {John M.} and Mastaglia, {Frank L.} and Changqing Zhang and Minghao Zheng and Junjie Gao",
year = "2019",
month = "5",
day = "7",
doi = "10.3233/JAD-181249",
language = "English",
volume = "69",
pages = "59--70",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "1",

}

The potential influence of bone-derived modulators on the progression of Alzheimer's disease. / Yuan, Jun; Meloni, Bruno P.; Shi, Tianxing; Bonser, Anne; Papadimitriou, John M.; Mastaglia, Frank L.; Zhang, Changqing; Zheng, Minghao; Gao, Junjie.

In: Journal of Alzheimer's Disease, Vol. 69, No. 1, 07.05.2019, p. 59-70.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The potential influence of bone-derived modulators on the progression of Alzheimer's disease

AU - Yuan, Jun

AU - Meloni, Bruno P.

AU - Shi, Tianxing

AU - Bonser, Anne

AU - Papadimitriou, John M.

AU - Mastaglia, Frank L.

AU - Zhang, Changqing

AU - Zheng, Minghao

AU - Gao, Junjie

PY - 2019/5/7

Y1 - 2019/5/7

N2 - Bone, the major structural scaffold of the human body, has recently been demonstrated to interact with several other organ systems through the actions of bone-derived cells and bone-derived cell secretory proteins. Interestingly, the brain is one organ that appears to fall into this interconnected network. Furthermore, the fact that osteoporosis and Alzheimer's disease are two common age-related disorders raises the possibility that these two organ systems are interconnected in terms of disease pathogenesis. This review focuses on the latest evidence demonstrating the impact of bone-derived cells and bone-derived proteins on the central nervous system, and on how this may be relevant in the progression of Alzheimer's disease and for the identification of novel therapeutic approaches to treat this neurodegenerative disorder.

AB - Bone, the major structural scaffold of the human body, has recently been demonstrated to interact with several other organ systems through the actions of bone-derived cells and bone-derived cell secretory proteins. Interestingly, the brain is one organ that appears to fall into this interconnected network. Furthermore, the fact that osteoporosis and Alzheimer's disease are two common age-related disorders raises the possibility that these two organ systems are interconnected in terms of disease pathogenesis. This review focuses on the latest evidence demonstrating the impact of bone-derived cells and bone-derived proteins on the central nervous system, and on how this may be relevant in the progression of Alzheimer's disease and for the identification of novel therapeutic approaches to treat this neurodegenerative disorder.

KW - Alzheimer's disease

KW - bone

KW - mesenchymal stem cells

KW - microglia

KW - osteocalcin

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U2 - 10.3233/JAD-181249

DO - 10.3233/JAD-181249

M3 - Review article

VL - 69

SP - 59

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JO - Journal of Alzheimer's Disease

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SN - 1387-2877

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ER -