The poliovirus receptor related 2 (PRR2) and apolipoprotein E genes and coronary heart disease

E.M. Freitas, Tony Phan, C.E. Herbison, Frank Christiansen, R.R. Taylor, Frank Van Bockxmeer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background Recently, we localized the Human Poliovirus Receptor Related 2 Gene (PRR2) 17kb centromeric to the gene for apolipoprotein E (APOE). Common polymorphisms in the latter have been found, in some studies, to be related to coronary heart disease (CHD) but the PRR2 gene has not been studied in this context. Here, we examined relationships between a PRR2 Sau961 (A/G) polymorphism, the epsilon2, 3 and 4 alleles of APOE and CHD.Design and methods Consecutive Caucasian patients (n=640) <50 years with angiographically documented coronary obstructive disease and/or with unequivocal myocardial infarction were compared with 624 control subjects, aged 30-50 years, randomly selected from the community and without a history of CHD.Results An excess of PRR2-A homozygotes was observed in cases (20% vs. 15%; OR 1.4, CI 1.04-1.86, P=0.026) particularly in those with single vessel disease (OR 1.7, CI 1.2-2.4, P
Original languageEnglish
Pages (from-to)59-65
JournalJournal of Cardiovascular Risk
Volume9
DOIs
Publication statusPublished - 2002

    Fingerprint

Cite this

Freitas, E. M., Phan, T., Herbison, C. E., Christiansen, F., Taylor, R. R., & Van Bockxmeer, F. (2002). The poliovirus receptor related 2 (PRR2) and apolipoprotein E genes and coronary heart disease. Journal of Cardiovascular Risk, 9, 59-65. https://doi.org/10.1097/00043798-200202000-00009