The pharmacology and oxidative stress effects of frusemide in acute kidney injury

Benjamin Isaac Silbert

doi:10.4225/23/5aa09bf435fbd

The pharmacology and oxidative stress effects of frusemide in acute kidney injury

Benjamin Isaac Silbert

UWA Medical School

Research output: Thesis › Master's Thesis

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Abstract

Acute kidney injury is common in critically ill patients. Frusemide is frequently administered to increase urine output, but
evidence to guide clinicians in this context is minimal. Animal data suggests frusemide may also limit progression by reducing
oxygen demand. In this thesis, 30 patients with acute kidney injury received intravenous frusemide to investigate pharmacology and renal oxygen demand. The results showed less frusemide reaches target receptors, and that which does has a reduced diuretic effect. A possible harmful effect on oxygen balance was also observed. These results caution against using frusemide to improve or prevent progression of acute kidney injury.

Original language	English
Qualification	Masters
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Mori, Trevor, Supervisor Ho, Kwok-ming, Supervisor
Award date	14 Feb 2018
DOIs	https://doi.org/10.4225/23/5aa09bf435fbd
Publication status	Unpublished - 2018

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10.4225/23/5aa09bf435fbd

THESIS - MASTER BY RESEARCH - SILBERT Benjamin Isaac - 2018
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Cite this

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title = "The pharmacology and oxidative stress effects of frusemide in acute kidney injury",

abstract = "Acute kidney injury is common in critically ill patients. Frusemide is frequently administered to increase urine output, but evidence to guide clinicians in this context is minimal. Animal data suggests frusemide may also limit progression by reducing oxygen demand. In this thesis, 30 patients with acute kidney injury received intravenous frusemide to investigate pharmacology and renal oxygen demand. The results showed less frusemide reaches target receptors, and that which does has a reduced diuretic effect. A possible harmful effect on oxygen balance was also observed. These results caution against using frusemide to improve or prevent progression of acute kidney injury.",

keywords = "acute kidney injury, renal failure, frusemide, diuretic, pharmacokinetics, pharmacodynamics, oxidative stress, F2 isoprostanes",

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AU - Silbert, Benjamin Isaac

PY - 2018

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N2 - Acute kidney injury is common in critically ill patients. Frusemide is frequently administered to increase urine output, but evidence to guide clinicians in this context is minimal. Animal data suggests frusemide may also limit progression by reducing oxygen demand. In this thesis, 30 patients with acute kidney injury received intravenous frusemide to investigate pharmacology and renal oxygen demand. The results showed less frusemide reaches target receptors, and that which does has a reduced diuretic effect. A possible harmful effect on oxygen balance was also observed. These results caution against using frusemide to improve or prevent progression of acute kidney injury.

AB - Acute kidney injury is common in critically ill patients. Frusemide is frequently administered to increase urine output, but evidence to guide clinicians in this context is minimal. Animal data suggests frusemide may also limit progression by reducing oxygen demand. In this thesis, 30 patients with acute kidney injury received intravenous frusemide to investigate pharmacology and renal oxygen demand. The results showed less frusemide reaches target receptors, and that which does has a reduced diuretic effect. A possible harmful effect on oxygen balance was also observed. These results caution against using frusemide to improve or prevent progression of acute kidney injury.

KW - acute kidney injury

KW - renal failure

KW - frusemide

KW - diuretic

KW - pharmacokinetics

KW - pharmacodynamics

KW - oxidative stress

KW - F2 isoprostanes

U2 - 10.4225/23/5aa09bf435fbd

DO - 10.4225/23/5aa09bf435fbd

M3 - Master's Thesis

ER -

The pharmacology and oxidative stress effects of frusemide in acute kidney injury

Abstract

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