The pharmacology and oxidative stress effects of frusemide in acute kidney injury

Benjamin Isaac Silbert

Research output: ThesisMaster's Thesis

203 Downloads (Pure)

Abstract

Acute kidney injury is common in critically ill patients. Frusemide is frequently administered to increase urine output, but
evidence to guide clinicians in this context is minimal. Animal data suggests frusemide may also limit progression by reducing
oxygen demand. In this thesis, 30 patients with acute kidney injury received intravenous frusemide to investigate pharmacology and renal oxygen demand. The results showed less frusemide reaches target receptors, and that which does has a reduced diuretic effect. A possible harmful effect on oxygen balance was also observed. These results caution against using frusemide to improve or prevent progression of acute kidney injury.
Original languageEnglish
QualificationMasters
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Mori, Trevor, Supervisor
  • Ho, Kwok-ming, Supervisor
Award date14 Feb 2018
DOIs
Publication statusUnpublished - 2018

Fingerprint Dive into the research topics of 'The pharmacology and oxidative stress effects of frusemide in acute kidney injury'. Together they form a unique fingerprint.

Cite this