TY - JOUR
T1 - The periconceptional environment and cardiovascular disease
T2 - Does in vitro embryo culture and transfer influence cardiovascular development and health?
AU - Padhee, Monalisa
AU - Zhang, Song
AU - Lie, Shervi
AU - Wang, Kimberley C
AU - Botting, Kimberley J
AU - McMillen, I Caroline
AU - Maclaughlin, Severence M
AU - Morrison, Janna L
PY - 2015/2/18
Y1 - 2015/2/18
N2 - Assisted Reproductive Technologies (ARTs) have revolutionised reproductive medicine; however, reports assessing the effects of ARTs have raised concerns about the immediate and long-term health outcomes of the children conceived through ARTs. ARTs include manipulations during the periconceptional period, which coincides with an environmentally sensitive period of gamete/embryo development and as such may alter cardiovascular development and health of the offspring in postnatal life. In order to identify the association between ARTs and cardiovascular health outcomes, it is important to understand the events that occur during the periconceptional period and how they are affected by procedures involved in ARTs. This review will highlight the emerging evidence implicating adverse cardiovascular outcomes before and after birth in offspring conceived through ARTs in both human and animal studies. In addition, it will identify the potential underlying causes and molecular mechanisms responsible for the congenital and adult cardiovascular dysfunctions in offspring whom were conceived through ARTs.
AB - Assisted Reproductive Technologies (ARTs) have revolutionised reproductive medicine; however, reports assessing the effects of ARTs have raised concerns about the immediate and long-term health outcomes of the children conceived through ARTs. ARTs include manipulations during the periconceptional period, which coincides with an environmentally sensitive period of gamete/embryo development and as such may alter cardiovascular development and health of the offspring in postnatal life. In order to identify the association between ARTs and cardiovascular health outcomes, it is important to understand the events that occur during the periconceptional period and how they are affected by procedures involved in ARTs. This review will highlight the emerging evidence implicating adverse cardiovascular outcomes before and after birth in offspring conceived through ARTs in both human and animal studies. In addition, it will identify the potential underlying causes and molecular mechanisms responsible for the congenital and adult cardiovascular dysfunctions in offspring whom were conceived through ARTs.
KW - Assisted reproductive technology
KW - Cardiovascular disease
KW - Epigenetics
KW - In vitro fertilization
KW - Periconceptional period
UR - http://www.scopus.com/inward/record.url?scp=84923164397&partnerID=8YFLogxK
U2 - 10.3390/nu7031378
DO - 10.3390/nu7031378
M3 - Review article
C2 - 25699984
AN - SCOPUS:84923164397
SN - 2072-6643
VL - 7
SP - 1378
EP - 1425
JO - Nutrients
JF - Nutrients
IS - 3
ER -