The pathogenesis of human myopathies with particular reference to regeneration in duchenne muscular dystrophy

Research output: ThesisMaster's Thesis

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[Truncated abstract] It is now some eighty years since the conception of a group of diseases in which the primary abnormality is in the skeletal muscles of the body. Since the very important and basic separation of these conditions from the heterogeneous group of progressive atrophies of muscle many distinct entities have been delineated on the basis of clinical, biochemical, pathological and electro-physiological features. Recognition of the importance of the genetically determined muscular dystrophies as slowly crippling conditions which can be fatal in early adult life, of the inflammatory myopathies which can complicate various systemic disorders and of the not uncommon involvement of the skeletal muscles in metabolic and endocrine disorders has stimulated increasing interest in myopathology both on the part of the clinician and the pathologist. ... Although advances in the fields of biochemistry, cytochemistry and electronmicroscopy over the past two decades have led to the recognition of several new myopathies and thrown considerable light on the biochemical and fine structural changes in several of the others, our knowledge of the aetiology and pathogenesis of these conditions remains far from complete. Despite much research we still do not know the nature of the basic abnormality in the muscular dystrophies or in polymyositis nor the mechanisms whereby this leads to the observed lesions in the diseases. The present is principally a comparative morphological study of the myopathies with the emphasis on muscular dystrophy and polymyositis with a view to a better understanding of their pathogenesis and natural history.
Original languageEnglish
Publication statusUnpublished - 1968


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