The PACE Study: A Randomised Clinical Trial of Cognitive Activity Strategy Training for Older People with Mild Cognitive Impairment.

Mandy Vidovich, Nicola Lautenschlager, Leon Flicker, L. Clare, Kieran Mccaul, Osvaldo Almeida

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Objective
    The role of cognition-focused interventions in reducing cognitive decline in older people remains uncertain. This study aimed to clarify whether a group cognitive activity (CA) strategy-training program would decrease the 2-year rate of cognitive decline of people with mild cognitive impairment (MCI).

    Design
    Randomized controlled trial.

    Setting
    One study site.

    Participants
    160 older adults with MCI ≥65 years of age (mean: 75, SD: 5.8).

    Intervention
    Five-week CA strategy training or a control nonspecific educational program. The primary outcome measure was change from baseline in the total score on the Cambridge Cognitive Examination-Revised (CAMCOG-R). Secondary outcomes of interest included changes in memory, attention, executive functions, mood, and quality of life. Endpoints were collected 10, 52, and 104 weeks post baseline.

    Results
    Intention to treat analysis identified no significant difference in CAMCOG-R scores over time between the two groups (mean difference: −0.36, 95% CI: −1.02,0.29) or across secondary outcome measures. The exceptions were better performance of the CA group on immediate attention (Digit Span Forwards, adjusted mean difference: 0.15, 95% CI: 0.01,0.30) and better quality of life (adjusted mean difference: 0.57, 95% CI: 0.10,1.04) compared with controls.

    Conclusion
    The devised program of CA did not improve general cognitive performance of older adults with MCI over a period of 2 years. Although favorable, the beneficial effects of the intervention on attention and quality of life were small, and of uncertain significance.
    Original languageEnglish
    Pages (from-to)360–372
    JournalThe American Journal of Geriatric Psychiatry
    Volume23
    Issue number4
    DOIs
    Publication statusPublished - Apr 2015

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