The Optimization of Antenatal Corticosteroid Therapy

Tsukasa Takahashi

Research output: ThesisDoctoral Thesis

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Abstract

Antenatal steroid (ANS) therapy greatly improves outcomes for preterm infants; when administered
judiciously, it accelerates fetal lung maturation, yielding reduced risk of neonatal death and serious
disease. However, recent data have identified increased ANS risks, including neurodevelopmental
abnormalities, highlighting the fact that dosing for ANS therapy has never been optimised. This thesis
details the findings of work to optimise ANS therapy, using the sheep model of pregnancy. Key
findings are that continuous, low amplitude betamethasone concentrations were key to accelerating
preterm lung maturation, and equated with extended duration of benefit and improved treatment
reliability.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Payne, Matt, Supervisor
  • Kemp, Matthew, Supervisor
  • Newnham, John, Supervisor
  • Ireland, Demelza, Supervisor
Award date2 Oct 2023
DOIs
Publication statusUnpublished - 2023

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