The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug

M.S. Davies; Susan Berners-Price; J.W. Cox; N. Farrell

doi:10.1039/b209661g

The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug

M.S. Davies
, Susan Berners-Price
, J.W. Cox
, N. Farrell

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.

Original language	English
Pages (from-to)	122-123
Journal	Chemical Communications
Volume	1
DOIs	https://doi.org/10.1039/b209661g
Publication status	Published - 2003

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10.1039/b209661g

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abstract = "The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.",

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The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug

Abstract

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