The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug

M.S. Davies, Susan Berners-Price, J.W. Cox, N. Farrell

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.
Original languageEnglish
Pages (from-to)122-123
JournalChemical Communications
Volume1
DOIs
Publication statusPublished - 2003

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