TY - JOUR
T1 - The nature and frequency of outer retinal disruption in idiopathic multifocal choroiditis associated with persistent fundus hyperautofluorescence
AU - Kaden, Talia R.
AU - Gattoussi, Sarra
AU - Dolz-Marco, Rosa
AU - Balaratnasingam, Chandrakumar
AU - Yannuzzi, Lawrence A.
AU - Bailey Freund, K.
PY - 2019/11/22
Y1 - 2019/11/22
N2 - BACKGROUND AND OBJECTIVE: To describe the prevalence and anatomic correlates for hyperautofluorescence related to outer retinal disruption in eyes with multifocal choroiditis (MFC). PATIENTS AND METHODS: Retrospective review of MFC patients. RESULTS: Fifty-nine eyes from 37 patients were analyzed. Multimodal imaging was utilized to identify nine eyes (15.2%) of six patients with either transient (Group 1) or persistent (Group 2) regions of hyperautofluorescence associated with ellipsoid zone (EZ) disruption over intact retinal pigment epithelium (RPE). Group 1 included four eyes (6.8%) of three patients in which the hyperautofluorescence and EZ loss resolved within a few months (range: 28 days to 125 days) and had intact overlying outer nuclear (ONL) and outer plexiform layers (OPL) (mean follow-up: 1.3 years). Group 2 included five eyes (8.5%) of three patients with regions of permanent EZ disruption associated with absent or reduced ONL and OPL (mean follow-up: 4.6 years). CONCLUSIONS: Hyperautofluorescence correlating with EZ disruption over intact RPE is a rare occurrence in MFC. Evaluating outer retinal integrity by optical coherence tomography may help identify eyes with potential for EZ restoration, which may have implications regarding treatment strategies.
AB - BACKGROUND AND OBJECTIVE: To describe the prevalence and anatomic correlates for hyperautofluorescence related to outer retinal disruption in eyes with multifocal choroiditis (MFC). PATIENTS AND METHODS: Retrospective review of MFC patients. RESULTS: Fifty-nine eyes from 37 patients were analyzed. Multimodal imaging was utilized to identify nine eyes (15.2%) of six patients with either transient (Group 1) or persistent (Group 2) regions of hyperautofluorescence associated with ellipsoid zone (EZ) disruption over intact retinal pigment epithelium (RPE). Group 1 included four eyes (6.8%) of three patients in which the hyperautofluorescence and EZ loss resolved within a few months (range: 28 days to 125 days) and had intact overlying outer nuclear (ONL) and outer plexiform layers (OPL) (mean follow-up: 1.3 years). Group 2 included five eyes (8.5%) of three patients with regions of permanent EZ disruption associated with absent or reduced ONL and OPL (mean follow-up: 4.6 years). CONCLUSIONS: Hyperautofluorescence correlating with EZ disruption over intact RPE is a rare occurrence in MFC. Evaluating outer retinal integrity by optical coherence tomography may help identify eyes with potential for EZ restoration, which may have implications regarding treatment strategies.
UR - http://www.scopus.com/inward/record.url?scp=85075498789&partnerID=8YFLogxK
U2 - 10.3928/23258160-20191031-02
DO - 10.3928/23258160-20191031-02
M3 - Article
C2 - 31755966
AN - SCOPUS:85075498789
VL - 50
SP - 675
EP - 683
JO - Ophthalmic Surgery, Lasers and Imaging Retina
JF - Ophthalmic Surgery, Lasers and Imaging Retina
SN - 2325-8160
IS - 11
ER -